Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77546 | Target Info | |||
| Target Name | Diamine oxidase (AOC1) | ||||
| Synonyms | Kidney amine oxidase; KAO; Histaminase; Amiloride-binding protein; AOC1; ABP | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | AOC1 | ||||
| Biochemical Class | CH-NH(2) donor oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Pentamidine | Ligand Info | |||||
| Structure Description | Crystal structure of human diamine oxidase in complex with the inhibitor pentamidine | PDB:3HII | ||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | Yes | [1] |
| PDB Sequence |
PRKAGVFSDL
36 SNQELKAVHS46 FLWSKKELRL56 QPSSTTTMAK66 NTVFLIEMLL76 PKKYHVLRFL 86 DKGERHPVRE96 ARAVIFFGDQ106 EHPNVTEFAV116 GPLPGPCYMR126 ALSPRPGYQS 136 SWASRPISTA146 EYALLYHTLQ156 EATKPLHQFF166 LNTTGFSFQD176 CHDRCLAFTD 186 VAPRGVASGQ196 RRSWLIIQRY206 VEGYFLHPTG216 LELLVDHGST226 DAGHWAVEQV 236 WYNGKFYGSP246 EELARKYADG256 EVDVVVLEDP266 LEPPLFSSHK286 PRGDFPSPIH 296 VSGPRLVQPH306 GPRFRLEGNA316 VLYGGWSFAF326 RLRSSSGLQV336 LNVHFGGERI 346 AYEVSVQEAV356 ALYGGHTPAG366 MQTKYLDVGW376 GLGSVTHELA386 PGIDCPETAT 396 FLDTFHYYDA406 DDPVHYPRAL416 CLFEMPTGVP426 LRRHFNSNFK436 GGFNFYAGLK 446 GQVLVLRTTS456 TVYNDYIWDF467 IFYPNGVMEA477 KMHATGYVHA487 TFYTPEGLRH 497 GTRLHTHLIG507 NIHTHLVHYR517 VDLDVAGTKN527 SFQTLQMKLE537 NITNPWSPRH 547 RVVQPTLEQT557 QYSWERQAAF567 RFKRKLPKYL577 LFTSPQENPW587 GHKRSYRLQI 597 HSMADQVLPP607 GWQEEQAITW617 ARYPLAVTKY627 RESELCSSSI637 YHQNDPWDPP 647 VVFEQFLHNN657 ENIENEDLVA667 WVTVGFLHIP677 HSEDIPNTAT687 PGNSVGFLLR 697 PFNFFPEDPS707 LASRDTVIVW717 PRDNGPNYVQ727 RWIPEDRDCS737 MPPPFSYNGT 747 YRPV
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| Ligand Name: 6-hydroxydopa quinone | Ligand Info | |||||
| Structure Description | Crystal structure of human diamine oxidase in complex with the inhibitor berenil | PDB:3HIG | ||||
| Method | X-ray diffraction | Resolution | 2.09 Å | Mutation | Yes | [1] |
| PDB Sequence |
PRKAGVFSDL
36 SNQELKAVHS46 FLWSKKELRL56 QPSSTTTMAK66 NTVFLIEMLL76 PKKYHVLRFL 86 DKGERHPVRE96 ARAVIFFGDQ106 EHPNVTEFAV116 GPLPGPCYMR126 ALSPRPGYQS 136 SWASRPISTA146 EYALLYHTLQ156 EATKPLHQFF166 LNTTGFSFQD176 CHDRCLAFTD 186 VAPRGVASGQ196 RRSWLIIQRY206 VEGYFLHPTG216 LELLVDHGST226 DAGHWAVEQV 236 WYNGKFYGSP246 EELARKYADG256 EVDVVVLEDP266 LEPPLFSSHK286 PRGDFPSPIH 296 VSGPRLVQPH306 GPRFRLEGNA316 VLYGGWSFAF326 RLRSSSGLQV336 LNVHFGGERI 346 AYEVSVQEAV356 ALYGGHTPAG366 MQTKYLDVGW376 GLGSVTHELA386 PGIDCPETAT 396 FLDTFHYYDA406 DDPVHYPRAL416 CLFEMPTGVP426 LRRHFNSNFK436 GGFNFYAGLK 446 GQVLVLRTTS456 TVYNDYIWDF467 IFYPNGVMEA477 KMHATGYVHA487 TFYTPEGLRH 497 GTRLHTHLIG507 NIHTHLVHYR517 VDLDVAGTKN527 SFQTLQMKLE537 NITNPWSPRH 547 RVVQPTLEQT557 QYSWERQAAF567 RFKRKLPKYL577 LFTSPQENPW587 GHKRSYRLQI 597 HSMADQVLPP607 GWQEEQAITW617 ARYPLAVTKY627 RESELCSSSI637 YHQNDPWDPP 647 VVFEQFLHNN657 ENIENEDLVA667 WVTVGFLHIP677 HSEDIPNTAT687 PGNSVGFLLR 697 PFNFFPEDPS707 LASRDTVIVW717 PRDNGPNYVQ727 RWIPEDRDCS737 MPPPFSYNGT 747 YRPV
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Diminazene | Ligand Info | |||||
| Structure Description | Crystal structure of human diamine oxidase in complex with the inhibitor berenil | PDB:3HIG | ||||
| Method | X-ray diffraction | Resolution | 2.09 Å | Mutation | Yes | [1] |
| PDB Sequence |
PRKAGVFSDL
36 SNQELKAVHS46 FLWSKKELRL56 QPSSTTTMAK66 NTVFLIEMLL76 PKKYHVLRFL 86 DKGERHPVRE96 ARAVIFFGDQ106 EHPNVTEFAV116 GPLPGPCYMR126 ALSPRPGYQS 136 SWASRPISTA146 EYALLYHTLQ156 EATKPLHQFF166 LNTTGFSFQD176 CHDRCLAFTD 186 VAPRGVASGQ196 RRSWLIIQRY206 VEGYFLHPTG216 LELLVDHGST226 DAGHWAVEQV 236 WYNGKFYGSP246 EELARKYADG256 EVDVVVLEDP266 LEPPLFSSHK286 PRGDFPSPIH 296 VSGPRLVQPH306 GPRFRLEGNA316 VLYGGWSFAF326 RLRSSSGLQV336 LNVHFGGERI 346 AYEVSVQEAV356 ALYGGHTPAG366 MQTKYLDVGW376 GLGSVTHELA386 PGIDCPETAT 396 FLDTFHYYDA406 DDPVHYPRAL416 CLFEMPTGVP426 LRRHFNSNFK436 GGFNFYAGLK 446 GQVLVLRTTS456 TVYNDYIWDF467 IFYPNGVMEA477 KMHATGYVHA487 TFYTPEGLRH 497 GTRLHTHLIG507 NIHTHLVHYR517 VDLDVAGTKN527 SFQTLQMKLE537 NITNPWSPRH 547 RVVQPTLEQT557 QYSWERQAAF567 RFKRKLPKYL577 LFTSPQENPW587 GHKRSYRLQI 597 HSMADQVLPP607 GWQEEQAITW617 ARYPLAVTKY627 RESELCSSSI637 YHQNDPWDPP 647 VVFEQFLHNN657 ENIENEDLVA667 WVTVGFLHIP677 HSEDIPNTAT687 PGNSVGFLLR 697 PFNFFPEDPS707 LASRDTVIVW717 PRDNGPNYVQ727 RWIPEDRDCS737 MPPPFSYNGT 747 YRPV
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure and inhibition of human diamine oxidase. Biochemistry. 2009 Oct 20;48(41):9810-22. | ||||
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