Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T76630 Target Info
Target Name Cambridge pathology 1 antigen (CD52)
Synonyms Epididymal secretory protein E5; CDW52; CD52 antigen; CD52
Target Type Successful Target
Gene Name CD52
UniProt ID
CD52_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: O-Phosphoethanolamine Ligand Info
Structure Description Crystal structure of anti-GLD52 Fab complex with human GLD52 peptide mimetic PDB:6OBD
Method X-ray diffraction Resolution 2.20 Å Mutation No [1]
PDB Sequence
DTSQTSSPS
Residue
Distance (Å)
SER6
4.281
PRO11
4.325
Residue
Distance (Å)
SER12
1.852
References  Top
REF 1 Engineering an anti-CD52 antibody for enhanced deamidation stability. MAbs. 2019 Oct;11(7):1266-1275.

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