Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76285 | Target Info | |||
| Target Name | Phosphodiesterase I beta (ENPP3) | ||||
| Synonyms | Phosphodiesterase I/nucleotide pyrophosphatase 3; PDNP3; PD-Ibeta; NPP3; Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; E-NPP 3; CD203c | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ENPP3 | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: [3H]alphabeta-meATP | Ligand Info | |||||
| Structure Description | Human ectonucleotide pyrophosphatase / phosphodiesterase 3 (ENPP3, NPP3, CD203c), inactive (T205A), N594S, with alpha,beta-methylene-ATP (AMPCPP) | PDB:6C02 | ||||
| Method | X-ray diffraction | Resolution | 1.94 Å | Mutation | Yes | [1] |
| PDB Sequence |
GSCRKKCFDA
61 SFRGLENCRC71 DVACKDRGDC81 CWDFEDTCVE91 STRIWMCNKF101 RCGETRLEAS 111 LCSCSDDCLQ121 RKDCCADYKS131 VCQGETSWLE141 ENCDQCPEGF156 DLPPVILFSM 166 DGFRAEYLYT176 WDTLMPNINK186 LKTCGIHSKY196 MRAMYPTKAF206 PNHYTIVTGL 216 YPESHGIIDN226 NMYDVNLNKN236 FSLSSKEQNN246 PAWWHGQPMW256 LTAMYQGLKA 266 ATYFWPGSEV276 AINGSFPSIY286 MPYNGSVPFE296 ERISTLLKWL306 DLPKAERPRF 316 YTMYFEEPDS326 SGHAGGPVSA336 RVIKALQVVD346 HAFGMLMEGL356 KQRNLHNCVN 366 IILLADHGMD376 QTYCNKMEYM386 TDYFPRINFF396 YMYEGPAPRI406 RAHNIPHDFF 416 SFNSEEIVRN426 LSCRKPDQHF436 KPYLTPDLPK446 RLHYAKNVRI456 DKVHLFVDQQ 466 WLAVRSKSNT476 NCGGGNHGYN486 NEFRSMEAIF496 LAHGPSFKEK506 TEVEPFENIE 516 VYNLMCDLLR526 IQPAPNNGTH536 GSLNHLLKVP546 FYEPSHAEEV556 SKFSVCGFAN 566 PLPTESLDCF576 CPHLQNSTQL586 EQVNQMLSLT596 QEEITATVKV606 NLPFGRPRVL 616 QKNVDHCLLY626 HREYVSGFGK636 AMRMPMWSSY646 TVPQLGDTSP656 LPPTVPDCLR 666 ADVRVPPSES676 QKCSFYLADK686 NITHGFLYPP696 ASNRTSDSQY706 DALITSNLVP 716 MYEEFRKMWD726 YFHSVLLIKH736 ATERNGVNVV746 SGPIFDYNYD756 GHFDAPDEIT 766 KHLANTDVPI776 PTHYFVVLTS786 CKNKSHTPEN796 CPGWLDVLPF806 IIPHRPTNVE 816 SCPEGKPEAL826 WVEERFTAHI836 ARVRDVELLT846 GLDFYQDKVQ856 PVSEILQLKT 866 YLPTF
|
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ASP167
2.557
LYS204
2.466
ALA205
2.372
PHE206
2.833
HIS209
4.899
ASN226
2.015
ASN227
2.949
LEU239
2.753
GLN244
2.738
PHE270
2.966
TRP271
3.484
PRO272
2.728
GLY273
4.094
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for nucleotide recognition by the ectoenzyme CD203c. FEBS J. 2018 Jul;285(13):2481-2494. | ||||
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