Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T74425 Target Info
Target Name Glutaredoxin-2 (GLRX2)
Synonyms Glutaredoxin-2, mitochondrial; GRX2; CGI-133
Target Type Literature-reported Target
Gene Name GLRX2
UniProt ID
GLRX2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Glutathione Ligand Info
Structure Description The structure of dimeric human glutaredoxin 2 PDB:2HT9
Method X-ray diffraction Resolution 1.90 Å Mutation No [1]
PDB Sequence
LATAPVNQIQ
21
ETISDNCVVI
31
FSKTSCSYCT
41
MAKKLFHDMN
51
VNYKVVELDL
61

LEYGNQFQDA
71
LYKMTGERTV
81
PRIFVNGTFI
91
GGATDTHRLH
101
KEGKLLPLVH
111

QCYL
Residue
Distance (Å)
CYS37
3.668
TYR39
3.695
ARG79
4.229
THR80
3.159
VAL81
2.886
PRO82
3.887
Residue
Distance (Å)
ARG83
4.884
GLY93
3.357
ALA94
2.942
THR95
2.810
ASP96
4.768
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References  Top
REF 1 Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria. J Biol Chem. 2007 Feb 2;282(5):3077-82.

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