Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T74425 | Target Info | |||
| Target Name | Glutaredoxin-2 (GLRX2) | ||||
| Synonyms | Glutaredoxin-2, mitochondrial; GRX2; CGI-133 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GLRX2 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Glutathione | Ligand Info | |||
| Canonical SMILES | C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N | ||||
| InChI | 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1 | ||||
| InChIKey | RWSXRVCMGQZWBV-WDSKDSINSA-N | ||||
| PubChem Compound ID | 124886 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 2HT9 The structure of dimeric human glutaredoxin 2 | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
LATAPVNQIQ
21 ETISDNCVVI31 FSKTSCSYCT41 MAKKLFHDMN51 VNYKVVELDL61 LEYGNQFQDA 71 LYKMTGERTV81 PRIFVNGTFI91 GGATDTHRLH101 KEGKLLPLVH111 QCYL |
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| PDB ID: 2FLS Crystal structure of Human Glutaredoxin 2 complexed with glutathione | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [2] |
| PDB Sequence |
MPVNQIQETI
24 SDNCVVIFSK34 TSCSYCTMAK44 KLFHDMNVNY54 KVVELDLLEY64 GNQFQDALYK 74 MTGERTVPRI84 FVNGTFIGGA94 TDTHRLHKEG104 KLLPLVHQCY114 L |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria. J Biol Chem. 2007 Feb 2;282(5):3077-82. | ||||
| REF 2 | Crystal structure of Human Glutaredoxin 2 complexed with glutathione | ||||
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