Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T71377 | Target Info | |||
| Target Name | Interleukin 3 receptor alpha (IL3RA) | ||||
| Synonyms | Interleukin-3 receptor subunit alpha; IL3R; IL-3RA; IL-3R-alpha; IL-3R subunit alpha; IL-3 receptor subunit alpha; CD123 antigen; CD123 | ||||
| Target Type | Successful Target | ||||
| Gene Name | IL3RA | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Edetic acid | Ligand Info | |||||
| Structure Description | Cytokine-receptor complex | PDB:5UWC | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
ITNLRMKAKA
36 QQLTWECVKD55 ADYSMPAVNN65 SYCQFGAISL75 CEVTNYTVRV85 STWILFPENS 100 GKPWAGAENL110 TCWIHDVDFL120 SCSWAVGPGA130 PADVQYDLYL140 NVANRRQQYE 150 CLHYKTDAQG160 TRIGCRFDDI170 SRLSSGSQSS180 HILVRGRSAA190 FGIPCTDKFV 200 VFSQIEILTP210 PQMTAKCNKT220 HSFMHWKMRS230 HFNRKFRYEL240 QIQKRMQPVI 250 TEQVRDRTSF260 QLLNPGTYTV270 QIRARERVYE280 FLSAWSTPQR290 FEC |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A dual role for the N-terminal domain of the IL-3 receptor in cell signalling. Nat Commun. 2018 Jan 26;9(1):386. | ||||
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