Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T67272 | Target Info | |||
Target Name | Aminopeptidase N (ANPEP) | ||||
Synonyms | Myeloid plasma membrane glycoprotein CD13; Microsomal aminopeptidase; HAPN; Gp150; Aminopeptidase M; Alanyl aminopeptidase; ANPEP | ||||
Target Type | Clinical trial Target | ||||
Gene Name | ANPEP | ||||
Biochemical Class | Peptidase | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Bestatin | Ligand Info | |||||
Structure Description | Human aminopeptidase N (CD13) in complex with bestatin | PDB:4FYR | ||||
Method | X-ray diffraction | Resolution | 1.91 Å | Mutation | No | [1] |
PDB Sequence |
PDQSKAWNRY
74 RLPNTLKPDS84 YRVTLRPYLT94 PNDRGLYVFK104 GSSTVRFTCK114 EATDVIIIHS 124 KKLNYTLSQG134 HRVVLRGVGG144 SQPPDIDKTE154 LVEPTEYLVV164 HLKGSLVKDS 174 QYEMDSEFEG184 ELADDLAGFY194 RSEYMEGNVR204 KVVATTQMQA214 ADARKSFPCF 224 DEPAMKAEFN234 ITLIHPKDLT244 ALSNMLPKGP254 STPLPEDPNW264 NVTEFHTTPK 274 MSTYLLAFIV284 SEFDYVEKQA294 SNGVLIRIWA304 RPSAIAAGHG314 DYALNVTGPI 324 LNFFAGHYDT334 PYPLPKSDQI344 GLPDFNAGAM354 ENWGLVTYRE364 NSLLFDPLSS 374 SSSNKERVVT384 VIAHELAHQW394 FGNLVTIEWW404 NDLWLNEGFA414 SYVEYLGADY 424 AEPTWNLKDL434 MVLNDVYRVM444 AVDALASSHP454 LSTPASEINT464 PAQISELFDA 474 ISYSKGASVL484 RMLSSFLSED494 VFKQGLASYL504 HTFAYQNTIY514 LNLWDHLQEA 524 VNNRSIQLPT534 TVRDIMNRWT544 LQMGFPVITV554 DTSTGTLSQE564 HFLLDPDSNV 574 TRPSEFNYVW584 IVPITSIRDG594 RQQQDYWLID604 VRAQNDLFST614 SGNEWVLLNL 624 NVTGYYRVNY634 DEENWRKIQT644 QLQRDHSAIP654 VINRAQIIND664 AFNLASAHKV 674 PVTLALNNTL684 FLIEERQYMP694 WEAALSSLSY704 FKLMFDRSEV714 YGPMKNYLKK 724 QVTPLFIHFR734 NNTNNWREIP744 ENLMDQYSEV754 NAISTACSNG764 VPECEEMVSG 774 LFKQWMENPN784 NNPIHPNLRS794 TVYCNAIAQG804 GEEEWDFAWE814 QFRNATLVNE 824 ADKLRAALAC834 SKELWILNRY844 LSYTLNPDLI854 RKQDATSTII864 SITNNVIGQG 874 LVWDFVQSNW884 KKLFNDYGGG894 SFSFSNLIQA904 VTRRFSTEYE914 LQQLEQFKKD 924 NEETGFGSGT934 RALEQALEKT944 KANIKWVKEN954 KEVVLQWFTE964 NSK |
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|
GLN211
4.014
GLN213
3.108
ALA214
3.681
ALA351
3.608
GLY352
4.356
ALA353
3.159
MET354
4.302
GLU355
3.328
ARG381
4.449
VAL385
3.981
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References | Top | ||||
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REF 1 | The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing. J Biol Chem. 2012 Oct 26;287(44):36804-13. |
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