Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T67063 | Target Info | |||
Target Name | Charybdotoxin receptor beta-4 (BKbeta4) | ||||
Synonyms | KCNMB4; Calcium activated potassium KCNMA1 (maxiK) channel | ||||
Target Type | Clinical trial Target | ||||
Gene Name | KCNMB4 | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Cholesterol | Ligand Info | |||||
Structure Description | Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex | PDB:6V22 | ||||
Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
PDB Sequence |
AYEYTEAEDK
2016 SIRLGLFLII2026 SGVVSLFIFG2036 FCWLSPALQD2046 LQATEANCTV2056 LSVQQIGEVF 2066 ECTFTCGADC2076 RGTSQYPCVQ2086 VYVNNSESNS2096 RALLHSDEHQ2106 LLTNPKCSYI 2116 PPCKRENQKN2126 LESVMNWQQY2136 WKDEIGSQPF2146 TCYFNQHQRP2156 DDVLLHRTHD 2166 EIVLLHCFLW2176 PLVTFVVGVL2186 IVVLTICAKS2196 LAVKAEAMK
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Ligand Name: (1r)-2-{[(S)-{[(2s)-2,3-Dihydroxypropyl]oxy}(Hydroxy)phosphoryl]oxy}-1-[(Hexadecanoyloxy)methyl]ethyl (9z)-Octadec-9-Enoate | Ligand Info | |||||
Structure Description | Cryo-EM structure of Ca2+-free hsSlo1-beta4 channel complex | PDB:6V35 | ||||
Method | Electron microscopy | Resolution | 3.50 Å | Mutation | No | [1] |
PDB Sequence |
YEYTEAEDKS
2017 IRLGLFLIIS2027 GVVSLFIFGF2037 CWLSPALQDL2047 QATEANCTVL2057 SVQQIGEVFE 2067 CTFTCGADCR2077 GTSQYPCVQV2087 YVNNSESNSR2097 ALLHSDEHQL2107 LTNPKCSYIP 2117 PCKRENQKNL2127 ESVMNWQQYW2137 KDEIGSQPFT2147 CYFNQHQRPD2157 DVLLHRTHDE 2167 IVLLHCFLWP2177 LVTFVVGVLI2187 VVLTICAKSL2197 AVKAEAMK
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References | Top | ||||
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REF 1 | Molecular structures of the human Slo1 K(+) channel in complex with beta4. Elife. 2019 Dec 9;8:e51409. |
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