Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67063 | Target Info | |||
| Target Name | Charybdotoxin receptor beta-4 (BKbeta4) | ||||
| Synonyms | KCNMB4; Calcium activated potassium KCNMA1 (maxiK) channel | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | KCNMB4 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C | ||||
| InChI | 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 | ||||
| InChIKey | HVYWMOMLDIMFJA-DPAQBDIFSA-N | ||||
| PubChem Compound ID | 5997 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6V22 Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex | ||||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
AYEYTEAEDK
2016 SIRLGLFLII2026 SGVVSLFIFG2036 FCWLSPALQD2046 LQATEANCTV2056 LSVQQIGEVF 2066 ECTFTCGADC2076 RGTSQYPCVQ2086 VYVNNSESNS2096 RALLHSDEHQ2106 LLTNPKCSYI 2116 PPCKRENQKN2126 LESVMNWQQY2136 WKDEIGSQPF2146 TCYFNQHQRP2156 DDVLLHRTHD 2166 EIVLLHCFLW2176 PLVTFVVGVL2186 IVVLTICAKS2196 LAVKAEAMK
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| PDB ID: 6V35 Cryo-EM structure of Ca2+-free hsSlo1-beta4 channel complex | ||||||
| Method | Electron microscopy | Resolution | 3.50 Å | Mutation | No | [1] |
| PDB Sequence |
YEYTEAEDKS
2017 IRLGLFLIIS2027 GVVSLFIFGF2037 CWLSPALQDL2047 QATEANCTVL2057 SVQQIGEVFE 2067 CTFTCGADCR2077 GTSQYPCVQV2087 YVNNSESNSR2097 ALLHSDEHQL2107 LTNPKCSYIP 2117 PCKRENQKNL2127 ESVMNWQQYW2137 KDEIGSQPFT2147 CYFNQHQRPD2157 DVLLHRTHDE 2167 IVLLHCFLWP2177 LVTFVVGVLI2187 VVLTICAKSL2197 AVKAEAMK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular structures of the human Slo1 K(+) channel in complex with beta4. Elife. 2019 Dec 9;8:e51409. | ||||
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