Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T63883 Target Info
Target Name Dystroglycan (DAG1)
Synonyms Dystrophin-associated glycoprotein 1; Alpha-dystroglycan
Target Type Literature-reported Target
Gene Name DAG1
Biochemical Class Dystroglycan protein
UniProt ID
DAG1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Alpha-D-Mannose Ligand Info
Structure Description Crystal Structure of POMGNT2 in complex with UDP and mono-mannosyl peptide (379Man long peptide) PDB:7E9K
Method X-ray diffraction Resolution 2.05 Å Mutation No [1]
PDB Sequence
RTRGAIIQTP
3
TLGPIQPTR
Residue
Distance (Å)
THR-5
1.616
Residue
Distance (Å)
THR2
1.443
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Ligand Name: N-Acetyl-2-deoxy-2-amino-galactose Ligand Info
Structure Description Tetra-O-GalNAc glycosylated mucin sequence from alpha dystroglycan mucin domain PDB:2MK7
Method Solution NMR Resolution N.A. Mutation Yes [2]
PDB Sequence
PPTTTTKKP
Residue
Distance (Å)
PRO3
4.564
THR4
1.410
THR5
1.410
THR6
1.410
Residue
Distance (Å)
THR7
1.410
LYS8
2.360
LYS9
2.377
PRO10
3.897
References  Top
REF 1 The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on Alpha-dystroglycan. Genes Cells. 2021 Jul;26(7):485-494.
REF 2 Contrasting the conformational effects of Alpha-O-GalNAc and Alpha-O-Man glycan protein modifications and their impact on the mucin-like region of alpha-dystroglycan. Glycobiology. 2021 Jun 3;31(5):649-661.

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