Target Binding Site Detail

Content Navigation (  All   None )                                      
Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T63883 Target Info
Target Name Dystroglycan (DAG1)
Synonyms Dystrophin-associated glycoprotein 1; Alpha-dystroglycan
Target Type Literature-reported Target
Gene Name DAG1
Biochemical Class Dystroglycan protein
UniProt ID
DAG1_HUMAN
Ligand General Information  Top
Ligand Name Alpha-D-Mannose Ligand Info
Canonical SMILES C(C1C(C(C(C(O1)O)O)O)O)O
InChI 1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKey WQZGKKKJIJFFOK-PQMKYFCFSA-N
PubChem Compound ID 185698
Drug Binding Sites of Target  Top
PDB ID: 7E9K      Crystal Structure of POMGNT2 in complex with UDP and mono-mannosyl peptide (379Man long peptide)
Method X-ray diffraction Resolution 2.05 Å Mutation No [1]
PDB Sequence
RTRGAIIQTP
3
TLGPIQPTR
Residue
Distance (Å)
THR-5
1.616
Residue
Distance (Å)
THR2
1.443
PDB ID: 7E9L      Crystal Structure of POMGNT2 in complex with UDP and mono-mannosyl peptide (379Man short peptide)
Method X-ray diffraction Resolution 2.10 Å Mutation No [1]
PDB Sequence
QTPTLGPIQP
10
TR
Residue
Distance (Å)
GLN1
4.880
Residue
Distance (Å)
THR2
1.434
References  Top
REF 1 The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on Alpha-dystroglycan. Genes Cells. 2021 Jul;26(7):485-494.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.