Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62390 | Target Info | |||
| Target Name | Tyrosine 3-monooxygenase (TH) | ||||
| Synonyms | Tyrosine 3-hydroxylase; TH | ||||
| Target Type | Successful Target | ||||
| Gene Name | TH | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Dopamine | Ligand Info | |||||
| Structure Description | Atomic model of the EM-based structure of the full-length tyrosine hydroxylase in complex with dopamine (residues 40-497) in which the regulatory domain (residues 40-165) has been included only with the backbone atoms | PDB:6ZVP | ||||
| Method | Electron microscopy | Resolution | 4.00 Å | Mutation | No | [1] |
| PDB Sequence |
SLIEDARKER
49 EAAVAAAAAA59 VPSEPGDPLE69 AVAFEEKEGK79 AMLNLLFSPR89 ATKPSALSRA 99 VKVFETFEAK109 IHHLETRPAQ119 RPRAGGPHLE129 YFVRLEVRRG139 DLAALLSGVR 149 QVSEDVRSPA159 GPKVPWFPRK169 VSELDKCHHL179 VTKFDPDLDL189 DHPGFSDQVY 199 RQRRKLIAEI209 AFQYRHGDPI219 PRVEYTAEEI229 ATWKEVYTTL239 KGLYATHACG 249 EHLEAFALLE259 RFSGYREDNI269 PQLEDVSRFL279 KERTGFQLRP289 VAGLLSARDF 299 LASLAFRVFQ309 CTQYIRHASS319 PMHSPEPDCC329 HELLGHVPML339 ADRTFAQFSQ 349 DIGLASLGAS359 DEEIEKLSTL369 YWFTVEFGLC379 KQNGEVKAYG389 AGLLSSYGEL 399 LHCLSEEPEI409 RAFDPEAAAV419 QPYQDQTYQS429 VYFVSESFSD439 AKDKLRSYAS 449 RIQRPFSVKF459 DPYTLAIDVL469 DSPQAVRRSL479 EGVQDELDTL489 AHALSAIG |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun. 2022 Jan 10;13(1):74. | ||||
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