Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T60708 | Target Info | |||
| Target Name | Complement C5 (CO5) | ||||
| Synonyms | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 | ||||
| Target Type | Successful Target | ||||
| Gene Name | C5 | ||||
| Biochemical Class | Complement system | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: N-(2-Acetamido)Iminodiacetic Acid | Ligand Info | |||||
| Structure Description | Crystal structure of human complement C5 in complex with the K8 bovine knob domain peptide. | PDB:7AD7 | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
EQTYVISAPK
29 IFRVGASENI39 VIQVYGYTEA49 FDATISIKSY59 PDKKFSYSSG69 HVHLSSENKF 79 QNSAILTIQP89 KQLPGGQNPV99 SYVYLEVVSK109 HFSKSKRMPI119 TYDNGFLFIH 129 TDKPVYTPDQ139 SVKVRVYSLN149 DDLKPAKRET159 VLTFIDPEGS169 EVDMVEEIDH 179 IGIISFPDFK189 IPSNPRYGMW199 TIKAKYKEDF209 STTGTAYFEV219 KEYVLPHFSV 229 SIEPEYNFIG239 YKNFKNFEIT249 IKARYFYNKV259 VTEADVYITF269 GIREDLKDDQ 279 KEMMQTAMQN289 TMLINGIAQV299 TFDSETAVKE309 LSYYSLEDLN319 NKYLYIAVTV 329 IESTGGFSEE339 AEIPGIKYVL349 SPYKLNLVAT359 PLFLKPGIPY369 PIKVQVKDSL 379 DQLVGGVPVT389 LNAQTIDVNQ399 ETSDLDPSKS409 VTRVDDGVAS419 FVLNLPSGVT 429 VLEFNVKTDA439 PDLPEENQAR449 EGYRAIAYSS459 LSQSYLYIDW469 TDNHKALLVG 479 EHLNIIVTPK489 SPYIDKITHY499 NYLILSKGKI509 IHFGTREKFS519 DASYQSINIP 529 VTQNMVPSSR539 LLVYYIVTGE549 QTAELVSDSV559 WLNIEEKCGN569 QLQVHLSPDA 579 DAYSPGQTVS589 LNMATGMDSW599 VALAAVDSAV609 YGFQFLEKSD631 LGCGAGGGLN 641 NANVFHLAGL651 TFLTNANADD661 SQCKE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The allosteric modulation of complement C5 by knob domain peptides. Elife. 2021 Feb 11;10:e63586. | ||||
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