Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59929 | Target Info | |||
| Target Name | Thymidine phosphorylase (TYMP) | ||||
| Synonyms | TdRPase; TYMP; TP; Platelet-derived endothelial cell growth factor; PDECGF; PD-ECGF; Gliostatin | ||||
| Target Type | Successful Target | ||||
| Gene Name | TYMP | ||||
| Biochemical Class | Pentosyltransferase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Thymine | Ligand Info | |||||
| Structure Description | Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design | PDB:2J0F | ||||
| Method | X-ray diffraction | Resolution | 2.31 Å | Mutation | No | [1] |
| PDB Sequence |
KQLPELIRMK
43 RDGGRLSEAD53 IRGFVAAVVN63 GSAQGAQIGA73 MLMAIRLRGM83 DLEETSVLTQ 93 ALAQSGQQLE103 WPEAWRQQLV113 DKHSTGGVGD123 KVSLVLAPAL133 AACGCKVPMI 143 SGRGLGHTGG153 TLDKLESIPG163 FNVIQSPEQM173 QVLLDQAGCC183 IVGQSEQLVP 193 ADGILYAARD203 VTATVDSLPL213 ITASILSKKL223 VEGLSALVVD233 VKFGAGAVFP 243 NQEQARELAK253 TLVGVGASLG263 LRVAAALTAM273 DKPLGRCVGH283 ALEVEEALLC 293 MDGAGPPDLR303 DLVTTLGGAL313 LWLSGHAGTQ323 AQGAARVAAA333 LDDGSALGRF 343 ERMLAAQGVD353 PGLARALCSG363 SPAERRQLLP373 RAREQEELLA383 PADGTVELVR 393 ALPLALVLHE403 LGAGRSRAGE413 PLRLGVGAEL423 LVDVGQRLRR433 GTPWLRVHRD 443 GPALSGPQSR453 ALQEALVLSD463 RAPFAAPLPF473 AELVLP
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| Ligand Name: 5-Iodouracil | Ligand Info | |||||
| Structure Description | Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil | PDB:2WK6 | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [2] |
| PDB Sequence |
QLPELIRMKR
44 DGGRLSEADI54 RGFVAAVVNG64 SAQGAQIGAM74 LMAIRLRGMD84 LEETSVLTQA 94 LAQSGQQLEW104 PEAWRQQLVD114 KHSTGGVGDK124 VSLVLAPALA134 ACGCKVPMIS 144 GRGLGHTGGT154 LDKLESIPGF164 NVIQSPEQMQ174 VLLDQAGCCI184 VGQSEQLVPA 194 DGILYAARDV204 TATVDSLPLI214 TASILSKKLV224 EGLSALVVDV234 KFGGAAVFPN 244 QEQARELAKT254 LVGVGASLGL264 RVAAALTAMD274 KPLGRCVGHA284 LEVEEALLCM 294 DGAGPPDLRD304 LVTTLGGALL314 WLSGHAGTQA324 QGAARVAAAL334 DDGSALGRFE 344 RMLAAQGVDP354 GLARALCSGS364 PAERRQLLPR374 AREQEELLAP384 ADGTVELVRA 394 LPLALVLHEL404 GAGRSRAGEP414 LRLGVGAELL424 VDVGQRLRRG434 TPWLRVHRDG 444 PALSGPQSRA454 LQEALVLSDR464 APFAAPSPFA474 ELVLPPQ
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| Ligand Name: Tipiracil | Ligand Info | |||||
| Structure Description | Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor | PDB:1UOU | ||||
| Method | X-ray diffraction | Resolution | 2.11 Å | Mutation | No | [3] |
| PDB Sequence |
PKQLPELIRM
42 KRDGGRLSEA52 DIRGFVAAVV62 NGSAQGAQIG72 AMLMAIRLRG82 MDLEETSVLT 92 QALAQSGQQL102 EWPEAWRQQL112 VDKHSTGGVG122 DKVSLVLAPA132 LAACGCKVPM 142 ISGRGLGHTG152 GTLDKLESIP162 GFNVIQSPEQ172 MQVLLDQAGC182 CIVGQSEQLV 192 PADGILYAAR202 DVTATVDSLP212 LITASILSKK222 LVEGLSALVV232 DVKFGAVFPN 244 QEQARELAKT254 LVGVGASLGL264 RVAAALTAMD274 KPLGRCVGHA284 LEVEEALLCM 294 DGAGPPDLRD304 LVTTLGGALL314 WLSGHAGTQA324 QGAARVAAAL334 DDGSALGRFE 344 RMLAAQGVDP354 GLARALCSGS364 PAERRQLLPR374 AREQEELLAP384 ADGTVELVRA 394 LPLALVLHEL404 GALRLGVGAE422 LLVDVGQRLR432 RGTPWLRVHR442 DGPALSGPQS 452 RALQEALVLS462 DRAPFAAPLP472 FAELVLPP
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design. Biochem J. 2006 Oct 15;399(2):199-204. | ||||
| REF 2 | Structures of native human thymidine phosphorylase and in complex with 5-iodouracil. Biochem Biophys Res Commun. 2009 Sep 4;386(4):666-70. | ||||
| REF 3 | Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor. Structure. 2004 Jan;12(1):75-84. | ||||
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