Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59102 | Target Info | |||
| Target Name | Platelet-derived growth factor receptor beta (PDGFRB) | ||||
| Synonyms | Platelet-derived growth factor receptor 1; PDGFR1; PDGFR-beta; PDGFR-1; PDGFR; PDGF-R-beta; CD140b antigen; CD140b; CD140 antigen-like family member B; Beta-type platelet-derived growth factor receptor; Beta-PDGFR; Beta platelet-derived growth factor receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | PDGFRB | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose | Ligand Info | |||||
| Structure Description | The structure of a platelet derived growth factor receptor complex | PDB:3MJG | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
LVVTPPGPEL
42 VLNVSSTFVL52 TCSGSAPVVW62 ERMSQEPPQE72 MAKAQDGTFS82 SVLTLTNLTG 92 LDTGEYFCTH102 NDDERKRLYI118 FVPDPTVGFL128 PNDAEELFIF138 LTEITEITIP 148 CRVTDPQLVV158 TLHEKKGDVA168 LPVPYDHQRG178 FSGIFEDRSY188 ICKTTIGDRE 198 VDSDAYYVYR208 LQVSSINVSV218 NAVQTVVRQG228 ENITLMCIVI238 GNEVVNFEWT 248 YPRKESGRLV258 EPVTDFLLDM268 PYHIRSILHI278 PSAELEDSGT288 YTCNVTESVN 298 DHQDEKAINI308 TVVE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11307-12. | ||||
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