Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57654 | Target Info | |||
| Target Name | Influenza Polymerase basic protein 2 (Influ PB2) | ||||
| Synonyms | RNA-directed RNA polymerase subunit P3; Polymerase basic protein 2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | Influ PB2 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 1,4-Butanediol | Ligand Info | |||||
| Structure Description | Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Puerto Rico/8/34(h1n1) | PDB:4ENF | ||||
| Method | X-ray diffraction | Resolution | 1.32 Å | Mutation | No | [1] |
| PDB Sequence |
SSSFSFGGFT
329 FKRTSGSSVK339 REEEVLTGNL349 QTLKIRVHEG359 YEEFTMVGRR369 ATAILRKATR 379 RLIQLIVSGR389 DEQSIAEAII399 VAMVFSQEDC409 MIKAVRGDLN419 FVNRANQRLN 429 PMHQLLRHFQ439 KDAKVLFQNW449 GVEPIDNVMG459 MIGILPDMTP469 SIEMSMRGVR 479 ISKM
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| Ligand Name: 7N-Methyl-8-hydroguanosine-5'-triphosphate | Ligand Info | |||||
| Structure Description | P453H/I471T mutant of PB2 middle domain from influenza virus A/Puerto Rico/8/34(H1N1) with m7GTP | PDB:3WI1 | ||||
| Method | X-ray diffraction | Resolution | 1.93 Å | Mutation | Yes | [2] |
| PDB Sequence |
SFSFGGFTFK
331 RTSGSSVKRE341 EEVLTGNLQT351 LKIRVHEGYE361 EFTMVGRRAT371 AILRKATRRL 381 IQLIVSGRDE391 QSIAEAIIVA401 MVFSQEDCMI411 KAVRGDLNFV421 NRANQRLNPM 431 HQLLRHFQKD441 AKVLFQNWGV451 EHIDNVMGMI461 GILPDMTPST471 EMSMRGVRIS 481 KM
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus. J Biol Chem. 2013 Apr 19;288(16):11013-23. | ||||
| REF 2 | Conformational polymorphism of m7GTP in crystal structure of the PB2 middle domain from human influenza A virus. PLoS One. 2013 Nov 29;8(11):e82020. | ||||
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