Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T55610 Target Info
Target Name Hypoxia-inducible factor 1 alpha (HIF-1A)
Synonyms bHLHe78; Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; Member of PAS protein 1; MOP1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1 A; Hypoxia inducible factor 1; HIF1-alpha; HIF1 alpha; HIF-1alpha; HIF-1-alpha; HIF-1 alpha; Class E basic helix-loop-helix protein 78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Target Type Clinical trial Target
Gene Name HIF1A
UniProt ID
HIF1A_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: trans-4-hydroxy-proline Ligand Info
Structure Description pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol PDB:6GMR
Method X-ray diffraction Resolution 1.75 Å Mutation No [1]
PDB Sequence
EALAYIPMDD
570
DFQLR
Residue
Distance (Å)
LEU562
4.104
ALA563
1.331
Residue
Distance (Å)
TYR565
1.327
ILE566
4.715
Ligand Name: 2-(carboxymethylamino)-2-oxoacetic acid Ligand Info
Structure Description HIF prolyl hydroxylase 2 (PHD2-R281C/P317C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-1) PDB:5L9V
Method X-ray diffraction Resolution 1.83 Å Mutation Yes [2]
PDB Sequence
DACTLLAPAA
404
GDTIISLCF
Residue
Distance (Å)
PRO402
2.420
Residue
Distance (Å)
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Ligand Name: Alpha-ketoglutaric acid Ligand Info
Structure Description HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574) PDB:5L9B
Method X-ray diffraction Resolution 1.95 Å Mutation Yes [2]
PDB Sequence
LDLEMLAPYI
566
PMDDDFQL
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AKG or .AKG2 or .AKG3 or :3AKG;style chemicals stick;color identity;select .C:564; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
PRO564
3.363
Residue
Distance (Å)
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References  Top
REF 1 Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2018 Aug 23;61(16):7387-7393.
REF 2 Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun. 2016 Aug 26;7:12673.

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