Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T55610 Target Info
Target Name Hypoxia-inducible factor 1 alpha (HIF-1A)
Synonyms bHLHe78; Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; Member of PAS protein 1; MOP1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1 A; Hypoxia inducible factor 1; HIF1-alpha; HIF1 alpha; HIF-1alpha; HIF-1-alpha; HIF-1 alpha; Class E basic helix-loop-helix protein 78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Target Type Clinical trial Target
Gene Name HIF1A
UniProt ID
HIF1A_HUMAN
Ligand General Information  Top
Ligand Name Alpha-ketoglutaric acid Ligand Info
Canonical SMILES C(CC(=O)O)C(=O)C(=O)O
InChI 1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKey KPGXRSRHYNQIFN-UHFFFAOYSA-N
PubChem Compound ID 51
Drug Binding Sites of Target  Top
PDB ID: 1H2L      Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
Method X-ray diffraction Resolution 2.25 Å Mutation No [1]
PDB Sequence
LTSYDCEVNA
804
PILQGEELLR
820
AL
Residue
Distance (Å)
ASN803
4.901
Residue
Distance (Å)
PDB ID: 5L9B      HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Method X-ray diffraction Resolution 1.95 Å Mutation Yes [2]
PDB Sequence
LDLEMLAPYI
566
PMDDDFQL
Residue
Distance (Å)
PRO564
3.363
Residue
Distance (Å)
PDB ID: 5JWP      Crystal structure of human FIH D201E variant in complex with Zn, alpha-ketoglutarate, and HIF1 alpha peptide.
Method X-ray diffraction Resolution 2.10 Å Mutation Yes [3]
PDB Sequence
QLTSYDAEVN
803
API
Residue
Distance (Å)
ASN803
4.913
Residue
Distance (Å)
References  Top
REF 1 Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. J Biol Chem. 2003 Jan 17;278(3):1802-6.
REF 2 Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun. 2016 Aug 26;7:12673.
REF 3 The facial triad in the Alpha-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O(2) activation. J Inorg Biochem. 2017 Jan;166:26-33.

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