Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T53890 Target Info
Target Name Gankyrin (PSMD10)
Synonyms p28(GANK); 26S proteasome regulatory subunit p28; 26S proteasome non-ATPase regulatory subunit 10
Target Type Literature-reported Target
Gene Name PSMD10
UniProt ID
PSD10_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Urea Ligand Info
Structure Description Snapshots of Human PSMD10(Gankyrin) unfolding by urea: 1 hour incubation PDB:7VXW
Method X-ray diffraction Resolution 2.22 Å Mutation No [1]
PDB Sequence
GCVSNLMVCN
12
LAYSGKLEEL
22
KESILADKSL
32
ATRTDQDSRT
42
ALHWACSAGH
52

TEIVEFLLQL
62
GVPVNDKDDA
72
GWSPLHIAAS
82
AGRDEIVKAL
92
LGKGAQVNAV
102

NQNGCTPLHY
112
AASKNRHEIA
122
VMLLEGGANP
132
DAKDHYEATA
142
MHRAAAKGNL
152

KMIHILLYYK
162
ASTNIQDTEG
172
NTPLHLACDE
182
ERVEEAKLLV
192
SQGASIYIEN
202

KEEKTPLQVA
212
KGGLGLILKR
222
MVEG
Residue
Distance (Å)
ASN7
2.635
THR36
4.754
ASP37
4.093
GLN38
3.441
ASN117
2.879
ARG118
3.398
Residue
Distance (Å)
HIS119
2.736
GLU120
2.210
TYR160
2.608
TYR161
3.632
LYS162
3.305
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References  Top
REF 1 Snapshots of urea-induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution. Protein Sci. 2022 Dec;31(12):e4515.

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