Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53890 | Target Info | |||
| Target Name | Gankyrin (PSMD10) | ||||
| Synonyms | p28(GANK); 26S proteasome regulatory subunit p28; 26S proteasome non-ATPase regulatory subunit 10 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PSMD10 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Urea | Ligand Info | |||
| Canonical SMILES | C(=O)(N)N | ||||
| InChI | 1S/CH4N2O/c2-1(3)4/h(H4,2,3,4) | ||||
| InChIKey | XSQUKJJJFZCRTK-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 1176 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7VXW Snapshots of Human PSMD10(Gankyrin) unfolding by urea: 1 hour incubation | ||||||
| Method | X-ray diffraction | Resolution | 2.22 Å | Mutation | No | [1] |
| PDB Sequence |
GCVSNLMVCN
12 LAYSGKLEEL22 KESILADKSL32 ATRTDQDSRT42 ALHWACSAGH52 TEIVEFLLQL 62 GVPVNDKDDA72 GWSPLHIAAS82 AGRDEIVKAL92 LGKGAQVNAV102 NQNGCTPLHY 112 AASKNRHEIA122 VMLLEGGANP132 DAKDHYEATA142 MHRAAAKGNL152 KMIHILLYYK 162 ASTNIQDTEG172 NTPLHLACDE182 ERVEEAKLLV192 SQGASIYIEN202 KEEKTPLQVA 212 KGGLGLILKR222 MVEG
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| PDB ID: 7VY4 Snapshots of Human PSMD10(Gankyrin) unfolding by urea: 2 hours incubation | ||||||
| Method | X-ray diffraction | Resolution | 2.22 Å | Mutation | No | [1] |
| PDB Sequence |
GCVSNLMVCN
12 LAYSGKLEEL22 KESILADKSL32 ATRTDQDSRT42 ALHWACSAGH52 TEIVEFLLQL 62 GVPVNDKDDA72 GWSPLHIAAS82 AGRDEIVKAL92 LGKGAQVNAV102 NQNGCTPLHY 112 AASKNRHEIA122 VMLLEGGANP132 DAKDHYEATA142 MHRAAAKGNL152 KMIHILLYYK 162 ASTNIQDTEG172 NTPLHLACDE182 ERVEEAKLLV192 SQGASIYIEN202 KEEKTPLQVA 212 KGGLGLILKR222 MVEG
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| PDB ID: 7VY7 Snapshots of Human PSMD10(Gankyrin) unfolding by urea: 3 hours incubation | ||||||
| Method | X-ray diffraction | Resolution | 2.23 Å | Mutation | No | [1] |
| PDB Sequence |
GCVSNLMVCN
12 LAYSGKLEEL22 KESILADKSL32 ATRTDQDSRT42 ALHWACSAGH52 TEIVEFLLQL 62 GVPVNDKDDA72 GWSPLHIAAS82 AGRDEIVKAL92 LGKGAQVNAV102 NQNGCTPLHY 112 AASKNRHEIA122 VMLLEGGANP132 DAKDHYEATA142 MHRAAAKGNL152 KMIHILLYYK 162 ASTNIQDTEG172 NTPLHLACDE182 ERVEEAKLLV192 SQGASIYIEN202 KEEKTPLQVA 212 KGGLGLILKR222 MVEG
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Snapshots of urea-induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution. Protein Sci. 2022 Dec;31(12):e4515. | ||||
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