Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T50970 | Target Info | |||
| Target Name | Endothelin-converting enzyme 1 (ECE1) | ||||
| Synonyms | ECE-1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | ECE1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 5-(2-hydroxyethyl)nonane-1,9-diol | Ligand Info | |||||
| Structure Description | structure of human ECE-1 complexed with phosphoramidon | PDB:3DWB | ||||
| Method | X-ray diffraction | Resolution | 2.38 Å | Mutation | Yes | [1] |
| PDB Sequence |
SEACVSVTSS
110 ILSSMDPTVD120 PCHDFFSYAC130 GGWIKANPVP140 DGHSRWGTFS150 NLWEHNQAII 160 KHLLENSTAS170 VSEAERKAQV180 YYRACMNETR190 IEELRAKPLM200 ELIERLGGWN 210 ITGPWAKDNF220 QDTLQVVTAH230 YRTSPFFSVY240 VSADSKNSNS250 NVIQVDQSGL 260 GLPSRDYYLN270 KTENEKVLTG280 YLNYMVQLGK290 LLGGGDEEAI300 RPQMQQILDF 310 ETALANITIP320 QEKRRDEELI330 YHKVTAAELQ340 TLAPAINWLP350 FLNTIFYPVE 360 INESEPIVVY370 DKEYLEQIST380 LINTTDRCLL390 NNYMIWNLVR400 KTSSFLDQRF 410 QDADEKFMEV420 MWKFCVSDTE440 NNLGFALGPM450 FVKATFAEDS460 KSIATEIILE 470 IKKAFEESLS480 TLKWMDEETR490 KSAKEKADAI500 YNMIGYPNFI510 MDPKELDKVF 520 NDYTAVPDLY530 FENAMRFFNF540 SWRVTADQLR550 KAPNRDQWSM560 TPPMVNAYYS 570 PTKNEIVFPA580 GILQAPFYTR590 SSPKALNFGG600 IGVVVGHELT610 HAFDDQGREY 620 DKDGNLRPWW630 KNSSVEAFKR640 QTECMVEQYS650 NYSVNGEPVN660 GRHTLGENIA 670 DNGGLKAAYR680 AYQNWVKKNG690 AEHSLPTLGL700 TNNQLFFLGF710 AQVWCSVRTP 720 ESSHEGLITD730 PHSPSRFRVI740 GSLSNSKEFS750 EHFRCPPGSP760 MNPPHKCEVW 770
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| Ligand Name: Phosphoramidon | Ligand Info | |||||
| Structure Description | structure of human ECE-1 complexed with phosphoramidon | PDB:3DWB | ||||
| Method | X-ray diffraction | Resolution | 2.38 Å | Mutation | Yes | [1] |
| PDB Sequence |
SEACVSVTSS
110 ILSSMDPTVD120 PCHDFFSYAC130 GGWIKANPVP140 DGHSRWGTFS150 NLWEHNQAII 160 KHLLENSTAS170 VSEAERKAQV180 YYRACMNETR190 IEELRAKPLM200 ELIERLGGWN 210 ITGPWAKDNF220 QDTLQVVTAH230 YRTSPFFSVY240 VSADSKNSNS250 NVIQVDQSGL 260 GLPSRDYYLN270 KTENEKVLTG280 YLNYMVQLGK290 LLGGGDEEAI300 RPQMQQILDF 310 ETALANITIP320 QEKRRDEELI330 YHKVTAAELQ340 TLAPAINWLP350 FLNTIFYPVE 360 INESEPIVVY370 DKEYLEQIST380 LINTTDRCLL390 NNYMIWNLVR400 KTSSFLDQRF 410 QDADEKFMEV420 MWKFCVSDTE440 NNLGFALGPM450 FVKATFAEDS460 KSIATEIILE 470 IKKAFEESLS480 TLKWMDEETR490 KSAKEKADAI500 YNMIGYPNFI510 MDPKELDKVF 520 NDYTAVPDLY530 FENAMRFFNF540 SWRVTADQLR550 KAPNRDQWSM560 TPPMVNAYYS 570 PTKNEIVFPA580 GILQAPFYTR590 SSPKALNFGG600 IGVVVGHELT610 HAFDDQGREY 620 DKDGNLRPWW630 KNSSVEAFKR640 QTECMVEQYS650 NYSVNGEPVN660 GRHTLGENIA 670 DNGGLKAAYR680 AYQNWVKKNG690 AEHSLPTLGL700 TNNQLFFLGF710 AQVWCSVRTP 720 ESSHEGLITD730 PHSPSRFRVI740 GSLSNSKEFS750 EHFRCPPGSP760 MNPPHKCEVW 770
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ARG145
4.874
PHE149
3.171
MET560
3.905
VAL565
2.506
ASN566
2.485
ALA567
2.778
TYR568
4.030
TYR569
4.686
ILE582
3.301
PHE587
4.467
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human endothelin-converting enzyme I complexed with phosphoramidon. J Mol Biol. 2009 Jan 9;385(1):178-87. | ||||
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