Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09NAJ
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| Former ID |
DNC001121
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| Drug Name |
Phosphoramidon
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| Synonyms |
Talopeptin; 84235-60-9; L-Tryptophan, N-(N-(((6-deoxy-alpha-L-talopyranosyl)oxy)hydroxyphosphinyl)-L-leucyl)-; talopeptin (MKI); AC1Q5QPH; (2s)-2-({(2s)-2-[(hydroxy{[(2s,3r,4r,5s,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yl]oxy}phosphoryl)amino]-4-methylpentanoyl}amino)-3-(1h-indol-3-yl)propanoic acid(non-preferred name); SCHEMBL7155564; AC1L353S; CHEMBL1742968; LS-158133; N-(6-deoxy-alpha-talopyranosyloxyphospho)-leucyl-tryptophan; N-[N-[[(6-deoxy-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H34N3O10P
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| Canonical SMILES |
CC1C(C(C(C(O1)OP(=O)(NC(CC(C)C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)O)O)O)O)O
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| InChI |
1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12-,16-,17-,18-,19+,20+,23-/m0/s1
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| InChIKey |
ZPHBZEQOLSRPAK-XLCYBJAPSA-N
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| CAS Number |
CAS 36357-77-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:45353
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Endothelin-converting enzyme (ECE) | Target Info | Inhibitor | [1] |
| Neutral endopeptidase (MME) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Renin-angiotensin system | |||
| Hematopoietic cell lineage | ||||
| Protein digestion and absorption | ||||
| Alzheimer's disease | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | Metabolism of Angiotensinogen to Angiotensins | |||
| Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| Alzheimers Disease | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | In vitro enzymatic processing of radiolabelled big ET-1 in human kidney. Biochem Pharmacol. 1998 Mar 1;55(5):697-701. | |||
| REF 2 | Neprilysin, a novel target for ultraviolet B regulation of melanogenesis via melanocortins. J Invest Dermatol. 2000 Sep;115(3):381-7. | |||
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