Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47863 | Target Info | |||
| Target Name | Tumor-associated calcium signal transducer 1 (EPCAM) | ||||
| Synonyms | hEGP314; TROP1; TACSTD1; Major gastrointestinal tumor-associated protein GA733-2; MIC18; M4S1; M1S2; KSA; KS 1/4 antigen; Gastrointestinal carcinoma antigen GA733; GA733-2; Epithelial glycoprotein 314; Epithelial glycoprotein; Epithelial cell surface antigen; Epithelial cell adhesion molecule; Ep-CAM; EGP314; EGP; Cell surface glycoprotein Trop-1; CD326; Adenocarcinoma-associated antigen | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | EPCAM | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Pyroglutamic Acid | Ligand Info | |||||
| Structure Description | Crystal structure of extracellular part of human EpCAM | PDB:4MZV | ||||
| Method | X-ray diffraction | Resolution | 1.86 Å | Mutation | Yes | [1] |
| PDB Sequence |
EECVCENYKL
34 AVNCFVNNNR44 QCQCTSVGAQ54 NTVICSKLAA64 KCLVMKAEMQ74 GSKLGRRAKP 84 EGALQNNDGL94 YDPDCDESGL104 FKAKQCQGTS114 TCWCVNTAGV124 RRTDKDTEIT 134 CSERVRTYWI144 IIELKHKARE154 KPYDSKSLRT164 ALQKEITTRY174 QLDPKFITSI 184 LYENNVITID194 LVQQSSQKTQ204 NDVDIADVAY214 YFEKDVKGES224 LFHSKKMDLT 234 VNGEQLDLDP244 GQTLIYYVDE254 KAPEFSMQGL264 KH
|
|||||
|
|
||||||
| Ligand Name: Decyl-beta-D-maltopyranoside | Ligand Info | |||||
| Structure Description | Crystal structure of extracellular part of human EpCAM | PDB:4MZV | ||||
| Method | X-ray diffraction | Resolution | 1.86 Å | Mutation | Yes | [1] |
| PDB Sequence |
EECVCENYKL
34 AVNCFVNNNR44 QCQCTSVGAQ54 NTVICSKLAA64 KCLVMKAEMQ74 GSKLGRRAKP 84 EGALQNNDGL94 YDPDCDESGL104 FKAKQCQGTS114 TCWCVNTAGV124 RRTDKDTEIT 134 CSERVRTYWI144 IIELKHKARE154 KPYDSKSLRT164 ALQKEITTRY174 QLDPKFITSI 184 LYENNVITID194 LVQQSSQKTQ204 NDVDIADVAY214 YFEKDVKGES224 LFHSKKMDLT 234 VNGEQLDLDP244 GQTLIYYVDE254 KAPEFSMQGL264 KH
|
|||||
|
|
ILE146
3.605
LEU148
4.284
LEU166
3.801
GLU169
3.980
ILE170
3.719
ARG173
3.537
TYR174
3.500
ILE193
3.870
LEU195
4.479
VAL212
3.880
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure and its bearing towards an understanding of key biological functions of EpCAM. Nat Commun. 2014 Aug 28;5:4764. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.