Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U7QA
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| Former ID |
DNC002533
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| Drug Name |
Pyroglutamic Acid
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| Synonyms |
DL-Pyroglutamic acid; 149-87-1; 5-Oxopyrrolidine-2-carboxylic acid; 2-Pyrrolidone-5-carboxylic acid; DL-Proline, 5-oxo-; 5-OXOPROLINE; 5-Oxo-DL-proline; Pyroglutamate; D-(+)-Pyroglutamic Acid; DL-Glutamic Acid Lactam; Pyrrolidonecarboxylic acid; CHEBI:16010; ODHCTXKNWHHXJC-UHFFFAOYSA-N; MFCD00064322; 5-oxoprolinate; DL-Pidolic acid; (+)-Pyroglutamic acid; 5-OXO-2-PYRROLIDINECARBOXYLIC ACID; D-Pyroglutamate; (+)-2-Pyrrolidone-5-carboxylic acid; DL-5-Oxoproline; (D-5-Oxo-2-pyrrolidinecarboxylic acid); Proline,5-oxo-; 5-Oxoproline #
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C5H7NO3
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| Canonical SMILES |
C1CC(=O)NC1C(=O)O
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| InChI |
1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1
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| InChIKey |
ODHCTXKNWHHXJC-VKHMYHEASA-N
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| CAS Number |
CAS 98-79-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
95967, 427849, 605293, 3139885, 5078796, 8145045, 8150666, 10508678, 10539043, 14747636, 24438867, 24857617, 25621698, 26699389, 29820541, 36493859, 50086852, 51075644, 51075645, 57320250, 57566652, 57929548, 78579986, 81040399, 81040605, 85089081, 85089082, 85089083, 85246216, 87570275, 88834734, 92297653, 93621465, 103146210, 103205643, 104295009, 104668212, 117546335, 117609232, 124385330, 124812473, 125326244, 125341550, 125349968, 125377014, 126523585, 126595700, 126613855, 126678637, 126688131
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| ChEBI ID |
CHEBI:18183
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiogenin (ANG) | Target Info | Inhibitor | [2] |
| Orexin (HCRT) | Target Info | Inhibitor | [2] | |
| Pancreatic alpha-amylase (AMY2A) | Target Info | Inhibitor | [2] | |
| NetPath Pathway | IL2 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Reactome | Adherens junctions interactions | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4703). | |||
| REF 2 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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