Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T43814 | Target Info | |||
| Target Name | Toll/interleukin-1 receptor domain-containing adapter (TIRAP) | ||||
| Synonyms | Toll/interleukin-1 receptor domain-containing adapter protein; TIR domain-containing adapter protein; MyD88-2; MyD88 adapter-like protein; MAL; Adaptor protein Wyatt | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | TIRAP | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (2S,3S)-1,4-Dimercaptobutane-2,3-diol | Ligand Info | |||||
| Structure Description | S180L variant of TIR domain of Mal/TIRAP | PDB:3UB4 | ||||
| Method | X-ray diffraction | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
SSRWSKDYDV
88 CVCHSEEDLV98 AAQDLVSYLE108 GAIVSELCQA136 LSSSHCRVLL146 ITPGFLQDPW 156 CKYQMLQALT166 EAPGAEGCTI176 PLLLGLSRAA186 YPPELRFMYY196 VDGRGPDGGF 206 RQVKEAVMRY216 LQTLS
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling. PLoS One. 2012;7(4):e34202. | ||||
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