Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T43531 | Target Info | |||
| Target Name | Chloride channel protein 7 (ClC-7) | ||||
| Synonyms | H(+)/Cl(-) exchange transporter 7; ClC-7; Chloride channel 7 alpha subunit | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | CLCN7 | ||||
| Biochemical Class | Chloride channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Adenosine triphosphate | Ligand Info | |||||
| Structure Description | Structure of the human CLCN7-OSTM1 complex with ATP | PDB:7CQ5 | ||||
| Method | Electron microscopy | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
YESLDYDNSE
103 NQLFLEEERR113 INHTAFRTVE123 IKRWVICALI133 GILTGLVACF143 IDIVVENLAG 153 LKYRVIKGNI163 DKFTEKGGLS173 FSLLLWATLN183 AAFVLVGSVI193 VAFIEPVAAG 203 SGIPQIKCFL213 NGVKIPHVVR223 LKTLVIKVSG233 VILSVVGGLA243 VGKEGPMIHS 253 GSVIAAGISQ263 GRSTSLKRDF273 KIFEYFRRDT283 EKRDFVSAGA293 AAGVSAAFGA 303 PVGGVLFSLE313 EGASFWNQFL323 TWRIFFASMI333 STFTLNFVLS343 IYHGNMWDLS 353 SPGLINFGRF363 DSEKMAYTIH373 EIPVFIAMGV383 VGGVLGAVFN393 ALNYWLTMFR 403 IRYIHRPCLQ413 VIEAVLVAAV423 TATVAFVLIY433 SSRDCQPLQG443 GSMSYPLQLF 453 CADGEYNSMA463 AAFFNTPEKS473 VVSLFHDPPG483 SYNPLTLGLF493 TLVYFFLACW 503 TYGLTVSAGV513 FIPSLLIGAA523 WGRLFGISLS533 YLTGAAIWAD543 PGKYALMGAA 553 AQLGGIVRMT563 LSLTVIMMEA573 TSNVTYGFPI583 MLVLMTAKIV593 GDVFIEGLYD 603 MHIQLQSVPF613 LHWEAPVTSH623 SLTAREVMST633 PVTCLRRREK643 VGVIVDVLSD 653 TASNHNGFPV663 VEARLQGLIL680 RSQLIVLLKH690 KVFVRRLRLK709 DFRDAYPRFP 719 PIQSIHVSQD729 ERECTMDLSE739 FMNPSPYTVP749 QEASLPRVFK759 LFRALGLRHL 769 VVVDNRNQVV779 GLVTRKDLAR789 Y
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TYR94
3.804
GLU95
3.371
SER96
2.983
SER632
3.269
PRO634
3.597
VAL635
3.869
THR636
3.293
SER656
4.104
ASN657
3.253
HIS658
2.627
ASN659
2.775
GLY660
2.529
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: adenosine diphosphate | Ligand Info | |||||
| Structure Description | Structure of the human CLCN7-OSTM1 complex with ADP | PDB:7CQ7 | ||||
| Method | Electron microscopy | Resolution | 3.55 Å | Mutation | No | [2] |
| PDB Sequence |
YESLDYDNSE
103 NQLFLEEERR113 INHTVEIKRW127 VICALIGILT137 GLVACFIDIV147 VENLAGLKYR 157 VIKGNIDKFT167 EKGGLSFSLL177 LWATLNAAFV187 LVGSVIVAFI197 EPVAAGSGIP 207 QIKCFLNGVK217 IPHVVRLKTL227 VIKVSGVILS237 VVGGLAVGKE247 GPMIHSGSVI 257 AAGISQGRST267 SLKRDFKIFE277 YFRRDTEKRD287 FVSAGAAAGV297 SAAFGAPVGG 307 VLFSLEEGAS317 FWNQFLTWRI327 FFASMISTFT337 LNFVLSIYHG347 NMWDLSSPGL 357 INFGRFDSEK367 MAYTIHEIPV377 FIAMGVVGGV387 LGAVFNALNY397 WLTMFRIRYI 407 HRPCLQVIEA417 VLVAAVTATV427 AFVLIYSSRD437 CQPLQGGSMS447 YPLQLFCADG 457 EYNSMAAAFF467 NTPEKSVVSL477 FHDPPGSYNP487 LTLGLFTLVY497 FFLACWTYGL 507 TVSAGVFIPS517 LLIGAAWGRL527 FGISLSYLTG537 AAIWADPGKY547 ALMGAAAQLG 557 GIVRMTLSLT567 VIMMEATSNV577 TYGFPIMLVL587 MTAKIVGDVF597 IEGLYDMHIQ 607 LQSVPFLHWE617 APVTSHSLTA627 REVMSTPVTC637 LRRREKVGVI647 VDVLSDTASN 657 HNGFPVVEAR674 LQGLILRSQL684 IVLLKHKVFR704 RLRLKDFRDA714 YPRFPPIQSI 724 HVSQDERECT734 MDLSEFMNPS744 PYTVPQEASL754 PRVFKLFRAL764 GLRHLVVVDN 774 RNQVVGLVTR784 KDLARY
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| Ligand Name: (2R)-3-{[(R)-hydroxy{[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrahydroxy-5-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dinonanoate | Ligand Info | |||||
| Structure Description | Structure of human CLC-7/OSTM1 complex | PDB:7JM7 | ||||
| Method | Electron microscopy | Resolution | 2.82 Å | Mutation | No | [3] |
| PDB Sequence |
SLKYESLDYD
100 NSENQLFLEE110 ERRINHTAFR120 TVEIKRWVIC130 ALIGILTGLV140 ACFIDIVVEN 150 LAGLKYRVIK160 GNIDKFTEKG170 GLSFSLLLWA180 TLNAAFVLVG190 SVIVAFIEPV 200 AAGSGIPQIK210 CFLNGVKIPH220 VVRLKTLVIK230 VSGVILSVVG240 GLAVGKEGPM 250 IHSGSVIAAG260 ISQGRSTSLK270 RDFKIFEYFR280 RDTEKRDFVS290 AGAAAGVSAA 300 FGAPVGGVLF310 SLEEGASFWN320 QFLTWRIFFA330 SMISTFTLNF340 VLSIYHGNLS 353 SPGLINFGRF363 DSEKMAYTIH373 EIPVFIAMGV383 VGGVLGAVFN393 ALNYWLTMFR 403 IRYIHRPCLQ413 VIEAVLVAAV423 TATVAFVLIY433 SSRDCQPLQG443 GSMSYPLQLF 453 CADGEYNSMA463 AAFFNTPEKS473 VVSLFHDPPG483 SYNPLTLGLF493 TLVYFFLACW 503 TYGLTVSAGV513 FIPSLLIGAA523 WGRLFGISLS533 YLTGAAIWAD543 PGKYALMGAA 553 AQLGGIVRMT563 LSLTVIMMEA573 TSNVTYGFPI583 MLVLMTAKIV593 GDVFIEGLYD 603 MHIQLQSVPF613 LHWEAPVTSH623 SLTAREVMST633 PVTCLRRREK643 VGVIVDVLSD 653 TASNHNGFPV663 VEARLQGLIL680 RSQLIVLLKH690 KVFVERRLRL708 KDFRDAYPRF 718 PPIQSIHVSQ728 DERECTMDLS738 EFMNPSPYTV748 PQEASLPRVF758 KLFRALGLRH 768 LVVVDNRNQV778 VGLVTRKDLA788 RYR
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0J1 or .0J12 or .0J13 or :30J1;style chemicals stick;color identity;select .A:128 or .A:132 or .A:136 or .A:137 or .A:139 or .A:140 or .A:143 or .A:219 or .A:220 or .A:221 or .A:222 or .A:223 or .A:224 or .A:225 or .A:227 or .A:256 or .A:257 or .A:259 or .A:260 or .A:261 or .A:262 or .A:263 or .A:264 or .A:265 or .A:266 or .A:267 or .A:268 or .A:269 or .A:273 or .A:275 or .A:276 or .A:285 or .A:715 or .A:716 or .A:717; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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VAL128
4.959
LEU132
2.544
LEU136
2.397
THR137
4.915
LEU139
2.465
VAL140
2.336
PHE143
4.878
PRO219
3.533
HIS220
4.413
VAL221
4.883
VAL222
2.209
ARG223
2.361
LEU224
2.468
LYS225
4.760
LEU227
2.435
VAL256
2.928
ILE257
2.211
ALA259
3.211
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of the human CLCN7-OSTM1 complex with ATP | ||||
| REF 2 | Structure of the human CLCN7-OSTM1 complex with ADP | ||||
| REF 3 | Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1. Elife. 2020 Aug 4;9:e59555. | ||||
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