Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T43531 | Target Info | |||
| Target Name | Chloride channel protein 7 (ClC-7) | ||||
| Synonyms | H(+)/Cl(-) exchange transporter 7; ClC-7; Chloride channel 7 alpha subunit | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | CLCN7 | ||||
| Biochemical Class | Chloride channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Adenosine triphosphate | Ligand Info | |||
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N | ||||
| InChI | 1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 | ||||
| InChIKey | ZKHQWZAMYRWXGA-KQYNXXCUSA-N | ||||
| PubChem Compound ID | 5957 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7JM7 Structure of human CLC-7/OSTM1 complex | ||||||
| Method | Electron microscopy | Resolution | 2.82 Å | Mutation | No | [1] |
| PDB Sequence |
SLKYESLDYD
100 NSENQLFLEE110 ERRINHTAFR120 TVEIKRWVIC130 ALIGILTGLV140 ACFIDIVVEN 150 LAGLKYRVIK160 GNIDKFTEKG170 GLSFSLLLWA180 TLNAAFVLVG190 SVIVAFIEPV 200 AAGSGIPQIK210 CFLNGVKIPH220 VVRLKTLVIK230 VSGVILSVVG240 GLAVGKEGPM 250 IHSGSVIAAG260 ISQGRSTSLK270 RDFKIFEYFR280 RDTEKRDFVS290 AGAAAGVSAA 300 FGAPVGGVLF310 SLEEGASFWN320 QFLTWRIFFA330 SMISTFTLNF340 VLSIYHGNLS 353 SPGLINFGRF363 DSEKMAYTIH373 EIPVFIAMGV383 VGGVLGAVFN393 ALNYWLTMFR 403 IRYIHRPCLQ413 VIEAVLVAAV423 TATVAFVLIY433 SSRDCQPLQG443 GSMSYPLQLF 453 CADGEYNSMA463 AAFFNTPEKS473 VVSLFHDPPG483 SYNPLTLGLF493 TLVYFFLACW 503 TYGLTVSAGV513 FIPSLLIGAA523 WGRLFGISLS533 YLTGAAIWAD543 PGKYALMGAA 553 AQLGGIVRMT563 LSLTVIMMEA573 TSNVTYGFPI583 MLVLMTAKIV593 GDVFIEGLYD 603 MHIQLQSVPF613 LHWEAPVTSH623 SLTAREVMST633 PVTCLRRREK643 VGVIVDVLSD 653 TASNHNGFPV663 VEARLQGLIL680 RSQLIVLLKH690 KVFVERRLRL708 KDFRDAYPRF 718 PPIQSIHVSQ728 DERECTMDLS738 EFMNPSPYTV748 PQEASLPRVF758 KLFRALGLRH 768 LVVVDNRNQV778 VGLVTRKDLA788 RYR
|
|||||
|
|
LEU92
4.273
TYR94
4.494
GLU95
3.054
SER96
2.380
SER632
2.284
THR633
4.507
PRO634
2.350
VAL635
2.308
THR636
2.191
CYS637
4.552
SER656
3.935
ASN657
2.569
HIS658
2.320
|
|||||
| PDB ID: 7CQ5 Structure of the human CLCN7-OSTM1 complex with ATP | ||||||
| Method | Electron microscopy | Resolution | 2.60 Å | Mutation | No | [2] |
| PDB Sequence |
YESLDYDNSE
103 NQLFLEEERR113 INHTAFRTVE123 IKRWVICALI133 GILTGLVACF143 IDIVVENLAG 153 LKYRVIKGNI163 DKFTEKGGLS173 FSLLLWATLN183 AAFVLVGSVI193 VAFIEPVAAG 203 SGIPQIKCFL213 NGVKIPHVVR223 LKTLVIKVSG233 VILSVVGGLA243 VGKEGPMIHS 253 GSVIAAGISQ263 GRSTSLKRDF273 KIFEYFRRDT283 EKRDFVSAGA293 AAGVSAAFGA 303 PVGGVLFSLE313 EGASFWNQFL323 TWRIFFASMI333 STFTLNFVLS343 IYHGNMWDLS 353 SPGLINFGRF363 DSEKMAYTIH373 EIPVFIAMGV383 VGGVLGAVFN393 ALNYWLTMFR 403 IRYIHRPCLQ413 VIEAVLVAAV423 TATVAFVLIY433 SSRDCQPLQG443 GSMSYPLQLF 453 CADGEYNSMA463 AAFFNTPEKS473 VVSLFHDPPG483 SYNPLTLGLF493 TLVYFFLACW 503 TYGLTVSAGV513 FIPSLLIGAA523 WGRLFGISLS533 YLTGAAIWAD543 PGKYALMGAA 553 AQLGGIVRMT563 LSLTVIMMEA573 TSNVTYGFPI583 MLVLMTAKIV593 GDVFIEGLYD 603 MHIQLQSVPF613 LHWEAPVTSH623 SLTAREVMST633 PVTCLRRREK643 VGVIVDVLSD 653 TASNHNGFPV663 VEARLQGLIL680 RSQLIVLLKH690 KVFVRRLRLK709 DFRDAYPRFP 719 PIQSIHVSQD729 ERECTMDLSE739 FMNPSPYTVP749 QEASLPRVFK759 LFRALGLRHL 769 VVVDNRNQVV779 GLVTRKDLAR789 Y
|
|||||
|
|
TYR94
3.804
GLU95
3.371
SER96
2.983
SER632
3.269
PRO634
3.597
VAL635
3.869
THR636
3.293
SER656
4.104
ASN657
3.253
HIS658
2.627
ASN659
2.775
GLY660
2.529
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1. Elife. 2020 Aug 4;9:e59555. | ||||
| REF 2 | Structure of the human CLCN7-OSTM1 complex with ATP | ||||
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