Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T42521 Target Info
Target Name Bacterial Shiga toxin 2 subunit B (Bact stxII)
Synonyms Stx2B protein; Stx2B; Stx2 holotoxin subunit B; Stx2 holotoxin B subunit; Shiga-like toxin type II B subunit; Shiga toxin subunit B; Shiga toxin 2v subunit A; Shiga toxin 2B; Shiga toxin 2, subunit B; Shiga toxin 2 B subunit
Target Type Clinical trial Target
Gene Name Bact stxII
UniProt ID
Q7DJJ2_ECOLX
Drug Binding Sites of Target  Top
Ligand Name: 3-(Pyridin-1-ium-1-yl)propane-1-sulfonate Ligand Info
Structure Description The crystal structure of Stx2 and a disaccharide ligand PDB:4M1U
Method X-ray diffraction Resolution 1.56 Å Mutation No [1]
PDB Sequence
ADCAKGKIEF
10
SKYNEDDTFT
20
VKVDGKEYWT
30
SRWNLQPLLQ
40
SAQLTGMTVT
50

IKSSTCESGS
60
GFAEVQFNND
70
Residue
Distance (Å)
LYS12
3.993
ASN14
3.674
GLU15
3.788
ASP16
3.202
Residue
Distance (Å)
THR18
3.602
THR20
4.342
TRP29
3.468
GLY59
4.899
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References  Top
REF 1 The crystal structure of shiga toxin type 2 with bound disaccharide guides the design of a heterobifunctional toxin inhibitor. J Biol Chem. 2014 Jan 10;289(2):885-94.

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