Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T42337 | Target Info | |||
| Target Name | Methionyl aminopeptidase 1 (METAP1) | ||||
| Synonyms | Peptidase M 1; Methionine aminopeptidase 1; MetAP 1; MAP 1; KIAA0094 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | METAP1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: L-methionine | Ligand Info | |||||
| Structure Description | HsMetAP in complex with methionine | PDB:4U6J | ||||
| Method | X-ray diffraction | Resolution | 1.56 Å | Mutation | No | [1] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 4-[4-(4-Methoxyphenyl)piperazin-1-Yl]-2-(Pyridin-2-Yl)quinazoline | Ligand Info | |||||
| Structure Description | Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 | PDB:4IU6 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [2] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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| Ligand Name: 3,4-Dihydroxy-2-methoxy-4-methyl-3-[2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-cyclohexanone | Ligand Info | |||||
| Structure Description | Human Type 1 methionine aminopeptidase in complex with ovalicin at 1.1 Ang | PDB:2GZ5 | ||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | No | [3] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OVA or .OVA2 or .OVA3 or :3OVA;style chemicals stick;color identity;select .A:192 or .A:195 or .A:198 or .A:203 or .A:211 or .A:212 or .A:229 or .A:240 or .A:300 or .A:301 or .A:302 or .A:303 or .A:309 or .A:310 or .A:336 or .A:338 or .A:353; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: N-hydroxy-1-[(3-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridine-5-carboxamide | Ligand Info | |||||
| Structure Description | crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with AN-P2-5H-06 | PDB:6LZB | ||||
| Method | X-ray diffraction | Resolution | 1.29 Å | Mutation | No | [4] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .EYF or .EYF2 or .EYF3 or :3EYF;style chemicals stick;color identity;select .A:192 or .A:195 or .A:196 or .A:198 or .A:203 or .A:212 or .A:229 or .A:231 or .A:240 or .A:242 or .A:303 or .A:309 or .A:310 or .A:336 or .A:352 or .A:353 or .A:367; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Nalpha-[5-Chloro-6-Methyl-2-(Pyridin-2-Yl)pyrimidin-4-Yl]-D-Phenylalaninamide | Ligand Info | |||||
| Structure Description | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide | PDB:4IKU | ||||
| Method | X-ray diffraction | Resolution | 1.30 Å | Mutation | No | [5] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SHX or .SHX2 or .SHX3 or :3SHX;style chemicals stick;color identity;select .A:128 or .A:192 or .A:195 or .A:196 or .A:198 or .A:203 or .A:212 or .A:300 or .A:301 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1-benzyl-N-hydroxypyrrolo[2,3-b]pyridine-4-carboxamide | Ligand Info | |||||
| Structure Description | crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with KV-P2-4H-05 | PDB:6LZC | ||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [4] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .EYL or .EYL2 or .EYL3 or :3EYL;style chemicals stick;color identity;select .A:192 or .A:195 or .A:196 or .A:198 or .A:203 or .A:212 or .A:229 or .A:230 or .A:231 or .A:240 or .A:242 or .A:303 or .A:309 or .A:310 or .A:336 or .A:352 or .A:353 or .A:367; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Tert-Butyl {2-[(1,3-Thiazol-2-Ylamino)carbonyl]pyridin-3-Yl}carbamate | Ligand Info | |||||
| Structure Description | Crystal structure of human methionine aminopeptidase type 1 in complex with 3-tert-Butoxycarbonylaminopyridine-2-carboxylic acid thiazole-2-ylamide | PDB:2NQ6 | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [6] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HM4 or .HM42 or .HM43 or :3HM4;style chemicals stick;color identity;select .A:128 or .A:192 or .A:195 or .A:196 or .A:198 or .A:203 or .A:212 or .A:300 or .A:301 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[(2,2-Dimethylpropanoyl)amino]-N-1,3-Thiazol-2-Ylpyridine-2-Carboxamide | Ligand Info | |||||
| Structure Description | Crystal structure of type 1 human methionine aminopeptidase in complex with 3-(2,2-Dimethylpropionylamino)pyridine-2-carboxylic acid thiazole-2-ylamide | PDB:2NQ7 | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [6] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HM5 or .HM52 or .HM53 or :3HM5;style chemicals stick;color identity;select .A:128 or .A:192 or .A:195 or .A:196 or .A:198 or .A:203 or .A:212 or .A:300 or .A:301 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-[5-Chloro-6-Methyl-2-(Pyridin-2-Yl)pyrimidin-4-Yl]-N'-[5-(Trifluoromethyl)pyridin-2-Yl]ethane-1,2-Diamine | Ligand Info | |||||
| Structure Description | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(5-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine | PDB:4IKT | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [5] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TFV or .TFV2 or .TFV3 or :3TFV;style chemicals stick;color identity;select .A:128 or .A:192 or .A:195 or .A:196 or .A:198 or .A:203 or .A:212 or .A:301 or .A:302 or .A:303 or .A:304 or .A:309 or .A:310 or .A:311 or .A:312 or .A:313 or .A:314 or .A:336 or .A:353; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-[5-Chloro-6-Methyl-2-(Pyridin-2-Yl)pyrimidin-4-Yl]-N'-[6-(Trifluoromethyl)pyridin-2-Yl]ethane-1,2-Diamine | Ligand Info | |||||
| Structure Description | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine | PDB:4IKS | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [5] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TFD or .TFD2 or .TFD3 or :3TFD;style chemicals stick;color identity;select .A:192 or .A:195 or .A:196 or .A:198 or .A:203 or .A:212 or .A:299 or .A:300 or .A:301 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-{4-[5-Chloro-6-Methyl-2-(Pyridin-2-Yl)pyrimidin-4-Yl]piperazin-1-Yl}ethanol | Ligand Info | |||||
| Structure Description | Crystal structure of Type 1 human methionine aminopeptidase in complex with 2-(4-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)piperazin-1-yl)ethanol | PDB:4IKR | ||||
| Method | X-ray diffraction | Resolution | 1.78 Å | Mutation | No | [5] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PVP or .PVP2 or .PVP3 or :3PVP;style chemicals stick;color identity;select .A:128 or .A:192 or .A:195 or .A:196 or .A:198 or .A:203 or .A:212 or .A:301 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (E,2r,3r,4s,5r)-N-(2,3-Dihydro-1h-Inden-2-Yl)-2-Methoxy-8,8-Dimethyl-3,4,5-Tris(Oxidanyl)non-6-Enamide | Ligand Info | |||||
| Structure Description | Human MetAP1 with bengamide analog Y10, in Mn form | PDB:4FLK | ||||
| Method | X-ray diffraction | Resolution | 1.47 Å | Mutation | No | [7] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y10 or .Y102 or .Y103 or :3Y10;style chemicals stick;color identity;select .A:192 or .A:195 or .A:198 or .A:203 or .A:211 or .A:212 or .A:229 or .A:231 or .A:240 or .A:242 or .A:300 or .A:301 or .A:302 or .A:303 or .A:309 or .A:310 or .A:314 or .A:336 or .A:338 or .A:353 or .A:365 or .A:367; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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PRO192
3.855
TYR195
3.655
PHE198
4.253
CYS203
3.531
CYS211
4.035
HIS212
2.886
ASP229
2.776
THR231
3.559
ASP240
3.212
ASN242
4.930
TYR300
3.844
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| Ligand Name: (E,2r,3r,4s,5r)-N-[(3r)-3-(Furan-2-Yl)-3-Phenyl-Propyl]-2-Methoxy-8,8-Dimethyl-3,4,5-Tris(Oxidanyl)non-6-Enamide | Ligand Info | |||||
| Structure Description | Human MetAP1 with bengamide analog YZ6, in Mn form | PDB:4FLL | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [7] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .YZ6 or .YZ62 or .YZ63 or :3YZ6;style chemicals stick;color identity;select .A:192 or .A:195 or .A:198 or .A:203 or .A:211 or .A:212 or .A:229 or .A:231 or .A:240 or .A:242 or .A:299 or .A:300 or .A:301 or .A:302 or .A:303 or .A:304 or .A:309 or .A:310 or .A:311 or .A:312 or .A:313 or .A:314 or .A:336 or .A:338 or .A:353 or .A:365 or .A:367; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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PRO192
3.841
TYR195
3.684
PHE198
4.168
CYS203
3.545
CYS211
4.109
HIS212
2.856
ASP229
2.800
THR231
3.480
ASP240
3.137
ASN242
4.828
SER299
3.736
TYR300
3.771
CYS301
2.824
GLY302
4.008
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| Ligand Name: (E,2R,3R,4S,5R)-N-(2-amino-2-oxo-ethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-non-6-enamide | Ligand Info | |||||
| Structure Description | Human MetAP1 with bengamide analog Y16, in Mn form | PDB:4FLI | ||||
| Method | X-ray diffraction | Resolution | 1.55 Å | Mutation | No | [7] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y16 or .Y162 or .Y163 or :3Y16;style chemicals stick;color identity;select .A:192 or .A:195 or .A:198 or .A:203 or .A:211 or .A:212 or .A:229 or .A:231 or .A:240 or .A:242 or .A:299 or .A:300 or .A:301 or .A:303 or .A:309 or .A:310 or .A:314 or .A:336 or .A:338 or .A:353 or .A:365 or .A:367; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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PRO192
3.801
TYR195
3.702
PHE198
4.236
CYS203
3.554
CYS211
4.104
HIS212
2.734
ASP229
2.763
THR231
3.610
ASP240
3.253
ASN242
4.845
SER299
4.290
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| Ligand Name: (E,2r,3r,4s,5r)-N-[[(3s)-1-Cyclopropylcarbonylpiperidin-3-Yl]methyl]-2-Methoxy-8,8-Dimethyl-3,4,5-Tris(Oxidanyl)non-6-Enamide | Ligand Info | |||||
| Structure Description | Human MetAP1 with bengamide analog Y08, in Mn form | PDB:4FLJ | ||||
| Method | X-ray diffraction | Resolution | 1.74 Å | Mutation | No | [7] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y08 or .Y082 or .Y083 or :3Y08;style chemicals stick;color identity;select .A:128 or .A:192 or .A:195 or .A:198 or .A:203 or .A:211 or .A:212 or .A:229 or .A:231 or .A:240 or .A:242 or .A:300 or .A:301 or .A:303 or .A:309 or .A:310 or .A:336 or .A:338 or .A:353 or .A:365 or .A:367; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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GLU128
3.548
PRO192
3.804
TYR195
3.594
PHE198
4.157
CYS203
3.524
CYS211
3.994
HIS212
2.848
ASP229
2.906
THR231
3.534
ASP240
3.110
ASN242
4.783
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| Ligand Name: [(1r)-1-Amino-2-Cyclohexylethyl]phosphonic Acid | Ligand Info | |||||
| Structure Description | HsMetAP (F309M) in complex with (1-amino-2-cyclohexylethyl)phosphonic acid | PDB:4U70 | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLM309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Q04 or .Q042 or .Q043 or :3Q04;style chemicals stick;color identity;select .A:191 or .A:192 or .A:195 or .A:198 or .A:203 or .A:212 or .A:229 or .A:231 or .A:240 or .A:242 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353 or .A:367; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: [(1r,2s)-1-Amino-2-Methylpentyl]phosphonic Acid | Ligand Info | |||||
| Structure Description | HsMetAP complex with (1-amino-2-methylpentyl)phosphonic acid | PDB:4U69 | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [1] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Q07 or .Q072 or .Q073 or :3Q07;style chemicals stick;color identity;select .A:192 or .A:195 or .A:198 or .A:203 or .A:212 or .A:229 or .A:231 or .A:240 or .A:242 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353 or .A:367; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: [(R)-Amino(Cyclohexyl)methyl]phosphonic Acid | Ligand Info | |||||
| Structure Description | HsMetAP(F309M) IN COMPLEX WITH 1- amino(cyclohexyl)methy)phosphonic acid | PDB:4U71 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLM309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Q03 or .Q032 or .Q033 or :3Q03;style chemicals stick;color identity;select .A:191 or .A:192 or .A:195 or .A:198 or .A:203 or .A:212 or .A:229 or .A:230 or .A:231 or .A:240 or .A:242 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353 or .A:367; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: [(R)-amino(phenyl)methyl]phosphonic acid | Ligand Info | |||||
| Structure Description | HsMetAP(F309M) IN COMPLEX WITH (amino(phenyl)methyl)phosphonic acid | PDB:4U73 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLM309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Q02 or .Q022 or .Q023 or :3Q02;style chemicals stick;color identity;select .A:192 or .A:195 or .A:198 or .A:203 or .A:212 or .A:229 or .A:230 or .A:231 or .A:240 or .A:242 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353 or .A:367; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: [(1r)-1-Amino-2-Propylpentyl]phosphonic Acid | Ligand Info | |||||
| Structure Description | HsMetAP (F220M) in complex with 1-amino-2-propylpentyl]phosphonic acid | PDB:4U6W | ||||
| Method | X-ray diffraction | Resolution | 1.83 Å | Mutation | Yes | [1] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLM309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Q08 or .Q082 or .Q083 or :3Q08;style chemicals stick;color identity;select .A:117 or .A:191 or .A:192 or .A:195 or .A:198 or .A:203 or .A:212 or .A:229 or .A:231 or .A:240 or .A:242 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353 or .A:367; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: [(1r)-1-Amino-3-Cyclopentylpropyl]phosphonic Acid | Ligand Info | |||||
| Structure Description | HsMetAP in complex with [(1R)-1-amino-3-cyclopentylpropyl]phosphonic acid | PDB:4U6C | ||||
| Method | X-ray diffraction | Resolution | 1.91 Å | Mutation | No | [1] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Q06 or .Q062 or .Q063 or :3Q06;style chemicals stick;color identity;select .A:192 or .A:195 or .A:198 or .A:203 or .A:212 or .A:229 or .A:231 or .A:240 or .A:242 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353 or .A:367; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (1r,2s,3s,4r)-4-Hydroxy-2-Methoxy-4-Methyl-3-[(2r,3r)-2-Methyl-3-(3-Methylbut-2-En-1-Yl)oxiran-2-Yl]cyclohexyl (Chloroacetyl)carbamate | Ligand Info | |||||
| Structure Description | Human methionine aminopeptidase type 1b (F309L mutant) in complex with TNP470 | PDB:5YR6 | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | Yes | [8] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLL309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TN4 or .TN42 or .TN43 or :3TN4;style chemicals stick;color identity;select .A:192 or .A:195 or .A:198 or .A:203 or .A:211 or .A:212 or .A:231 or .A:240 or .A:299 or .A:300 or .A:301 or .A:303 or .A:309 or .A:310 or .A:314 or .A:336 or .A:353; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 5-Chloro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine | Ligand Info | |||||
| Structure Description | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative | PDB:2G6P | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [9] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HM2 or .HM22 or .HM23 or :3HM2;style chemicals stick;color identity;select .A:192 or .A:195 or .A:196 or .A:198 or .A:203 or .A:212 or .A:300 or .A:301 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (1r)-N~2~-[5-Chloro-2-(5-Chloropyridin-2-Yl)-6-Methylpyrimidin-4-Yl]-1-Phenyl-N~1~-(4-Phenylbutyl)ethane-1,2-Diamine | Ligand Info | |||||
| Structure Description | Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1 | PDB:4HXX | ||||
| Method | X-ray diffraction | Resolution | 2.09 Å | Mutation | No | [10] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .1AY or .1AY2 or .1AY3 or :31AY;style chemicals stick;color identity;select .A:128 or .A:129 or .A:132 or .A:192 or .A:195 or .A:196 or .A:198 or .A:203 or .A:212 or .A:300 or .A:301 or .A:303 or .A:309 or .A:310 or .A:336 or .A:353; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases. J Med Chem. 2015 Mar 12;58(5):2350-7. | ||||
| REF 2 | Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem. 2013 May 23;56(10):3996-4016. | ||||
| REF 3 | Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase. Protein Sci. 2006 Aug;15(8):1842-8. | ||||
| REF 4 | Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studies. Bioorg Chem. 2021 Oct;115:105185. | ||||
| REF 5 | Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases. J Med Chem. 2013 Jul 11;56(13):5295-305. | ||||
| REF 6 | Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. | ||||
| REF 7 | Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases. J Med Chem. 2012 Sep 27;55(18):8021-7. | ||||
| REF 8 | Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis. Biochem J. 2019 Mar 22;476(6):991-1003. | ||||
| REF 9 | Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases. Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3772-5. | ||||
| REF 10 | Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem. 2013 May 1;21(9):2600-17. | ||||
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