Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T42337 | Target Info | |||
| Target Name | Methionyl aminopeptidase 1 (METAP1) | ||||
| Synonyms | Peptidase M 1; Methionine aminopeptidase 1; MetAP 1; MAP 1; KIAA0094 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | METAP1 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 3,4-Dihydroxy-2-methoxy-4-methyl-3-[2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-cyclohexanone | Ligand Info | |||
| Canonical SMILES | CC(=CCC1C(O1)(C)C2(C(C(=O)CCC2(C)O)OC)O)C | ||||
| InChI | 1S/C16H26O5/c1-10(2)6-7-12-15(4,21-12)16(19)13(20-5)11(17)8-9-14(16,3)18/h6,12-13,18-19H,7-9H2,1-5H3/t12-,13-,14-,15+,16-/m1/s1 | ||||
| InChIKey | UOXVFQCRPDLSFN-DGXTUMSLSA-N | ||||
| PubChem Compound ID | 5289086 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 2GZ5 Human Type 1 methionine aminopeptidase in complex with ovalicin at 1.1 Ang | ||||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | No | [1] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLF309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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| PDB ID: 5YKP Human methionine aminopeptidase type 1b (F309M mutant) in complex with ovalicin | ||||||
| Method | X-ray diffraction | Resolution | 1.68 Å | Mutation | Yes | [2] |
| PDB Sequence |
PYRYTGKLRP
98 HYPLMPTRPV108 PSYIQRPDYA118 DHPLGMSESE128 QALKGTSQIK138 LLSSEDIEGM 148 RLVCRLAREV158 LDVAAGMIKP168 GVTTEEIDHA178 VHLACIARNC188 YPSPLNYYNF 198 PKSCCTSVNE208 VICHGIPDRR218 PLQEGDIVNV228 DITLYRNGYH238 GDLNETFFVG 248 EVDDGARKLV258 QTTYECLMQA268 IDAVKPGVRY278 RELGNIIQKH288 AQANGFSVVR 298 SYCGHGIHKL308 MHTAPNVPHY318 AKNKAVGVMK328 SGHVFTIEPM338 ICEGGWQDET 348 WPDGWTAVTR358 DGKRSAQFEH368 TLLVTDTGCE378 ILTRRLDSAR388 PHFMS |
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| PDB ID: 5YR5 Human methionine aminopeptidase type 1b (F309L mutant) in complex with Ovalicin | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | Yes | [2] |
| PDB Sequence |
YRYTGKLRPH
99 YPLMPTRPVP109 SYIQRPDYAD119 HPLGMSESEQ129 ALKGTSQIKL139 LSSEDIEGMR 149 LVCRLAREVL159 DVAAGMIKPG169 VTTEEIDHAV179 HLACIARNCY189 PSPLNYYNFP 199 KSCCTSVNEV209 ICHGIPDRRP219 LQEGDIVNVD229 ITLYRNGYHG239 DLNETFFVGE 249 VDDGARKLVQ259 TTYECLMQAI269 DAVKPGVRYR279 ELGNIIQKHA289 QANGFSVVRS 299 YCGHGIHKLL309 HTAPNVPHYA319 KNKAVGVMKS329 GHVFTIEPMI339 CEGGWQDETW 349 PDGWTAVTRD359 GKRSAQFEHT369 LLVTDTGCEI379 LTRRLDSARP389 HFMS |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase. Protein Sci. 2006 Aug;15(8):1842-8. | ||||
| REF 2 | Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis. Biochem J. 2019 Mar 22;476(6):991-1003. | ||||
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