Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T41646 | Target Info | |||
| Target Name | Beta-arrestin-1 (ARRB1) | ||||
| Synonyms | Non-visual arrestin-2; Betaarrestin1; Arrestin beta1; Arrestin beta-1; ARR1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | ARRB1 | ||||
| Biochemical Class | Arrestin protein | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: L-serine-O-phosphate | Ligand Info | |||||
| Structure Description | Phosphorylated turkey beta1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in lipid nanodisc. | PDB:6TKO | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
TRVFKKASPN
15 GKLTVYLGKR25 DFVDHIDLVD35 PVDGVVLVDP45 EYLKERRVYV55 TLTCAFRYGR 65 EDCDVLGLTF75 RKDLFVANVQ85 SFPPAPEDKK95 PLTRLQERLI105 KKLGEHAYPF 115 TFEIPPNLPC125 SVTLQPGPED135 TGKACGVDYE145 VKAFCAENLE155 EKIHKRNSVR 165 LVIEKVQYAP175 ERPGPQPTAE185 TTRQFLMSDK195 PLHLEASLDK205 EIYYHGEPIS 215 VNVHVTNNTN225 KTVKKIKISV235 RQYADICLFN245 TAQYKCPVAM255 EEADDTVAPS 265 STFCKVYTLT275 PFLANNREKR285 GLALDGKLKH295 EDTNLASSTL305 LREGANREIL 315 GIIVSYKVKV325 KLVVSSDVAV345 ELPFTLMHPK355 PKEE
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | Phosphorylated turkey beta1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in lipid nanodisc. | PDB:6TKO | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
TRVFKKASPN
15 GKLTVYLGKR25 DFVDHIDLVD35 PVDGVVLVDP45 EYLKERRVYV55 TLTCAFRYGR 65 EDCDVLGLTF75 RKDLFVANVQ85 SFPPAPEDKK95 PLTRLQERLI105 KKLGEHAYPF 115 TFEIPPNLPC125 SVTLQPGPED135 TGKACGVDYE145 VKAFCAENLE155 EKIHKRNSVR 165 LVIEKVQYAP175 ERPGPQPTAE185 TTRQFLMSDK195 PLHLEASLDK205 EIYYHGEPIS 215 VNVHVTNNTN225 KTVKKIKISV235 RQYADICLFN245 TAQYKCPVAM255 EEADDTVAPS 265 STFCKVYTLT275 PFLANNREKR285 GLALDGKLKH295 EDTNLASSTL305 LREGANREIL 315 GIIVSYKVKV325 KLVVSSDVAV345 ELPFTLMHPK355 PKEE
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| Ligand Name: [(2r)-2-Octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-Tris(Oxidanyl)-4,5-Diphosphonooxy-Cyclohexyl]oxy-Phosphoryl]oxy-Propyl] Octanoate | Ligand Info | |||||
| Structure Description | neurotensin receptor and arrestin2 complex | PDB:6UP7 | ||||
| Method | Electron microscopy | Resolution | 4.20 Å | Mutation | Yes | [2] |
| PDB Sequence |
VFKKASPNGK
17 LTVYLGKRDF27 VDHIDLVDPV37 DGVVLVDPEY47 LKERRVYVTL57 TVAFRYGRED 67 LDVLGLTFRK77 DLFVANVQSF87 PPAPEDKKPL97 TRLQERLIKK107 LGEHAYPFTF 117 EIPPNLPSSV127 TLQPGPEDTG137 KALGVDYEVK147 AFVAENLEEK157 IHKRNSVRLV 167 IRKVQYAPER177 PGPQPTAETT187 RQFLMSDKPL197 HLEASLDKEI207 YYHGEPISVN 217 VHVTNNTNKT227 VKKIKISVRQ237 YADIVLFNTA247 QYKVPVAMEE257 ADDTVAPSST 267 FSKVYTLTPF277 LANNREKRGL287 ALDGKLKHED297 TNLASSTLLR307 EGANREILGI 317 IVSYKVKVKL327 VVSRGGLLGD337 LASSDVAVEL347 PFTLMHPK
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular basis of Beta-arrestin coupling to formoterol-bound Beta(1)-adrenoceptor. Nature. 2020 Jul;583(7818):862-866. | ||||
| REF 2 | Structure of the neurotensin receptor 1 in complex with beta-arrestin 1. Nature. 2020 Mar;579(7798):303-308. | ||||
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