Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T41646 | Target Info | |||
| Target Name | Beta-arrestin-1 (ARRB1) | ||||
| Synonyms | Non-visual arrestin-2; Betaarrestin1; Arrestin beta1; Arrestin beta-1; ARR1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | ARRB1 | ||||
| Biochemical Class | Arrestin protein | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-serine-O-phosphate | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 | ||||
| InChIKey | BZQFBWGGLXLEPQ-REOHCLBHSA-N | ||||
| PubChem Compound ID | 68841 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6TKO Phosphorylated turkey beta1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in lipid nanodisc. | ||||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
TRVFKKASPN
15 GKLTVYLGKR25 DFVDHIDLVD35 PVDGVVLVDP45 EYLKERRVYV55 TLTCAFRYGR 65 EDCDVLGLTF75 RKDLFVANVQ85 SFPPAPEDKK95 PLTRLQERLI105 KKLGEHAYPF 115 TFEIPPNLPC125 SVTLQPGPED135 TGKACGVDYE145 VKAFCAENLE155 EKIHKRNSVR 165 LVIEKVQYAP175 ERPGPQPTAE185 TTRQFLMSDK195 PLHLEASLDK205 EIYYHGEPIS 215 VNVHVTNNTN225 KTVKKIKISV235 RQYADICLFN245 TAQYKCPVAM255 EEADDTVAPS 265 STFCKVYTLT275 PFLANNREKR285 GLALDGKLKH295 EDTNLASSTL305 LREGANREIL 315 GIIVSYKVKV325 KLVVSSDVAV345 ELPFTLMHPK355 PKEE
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| PDB ID: 7SRS 5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM) | ||||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | Yes | [2] |
| PDB Sequence |
TRVFKKASPN
15 GKLTVYLGKR25 DFVDHIDLVD35 PVDGVVLVDP45 EYLKERRVYV55 TLTCAFRYGR 65 EDLDVLGLTF75 RKDLFVANVQ85 SFPPAPEDKK95 PLTRLQERLI105 KKLGEHAYPF 115 TFEIPPNLPC125 SVTLQPGPED135 TGKACGVDYE145 VKAFCAENLE155 EKIHKRNSVR 165 LVIEKVQYAP175 ERPGPQPTAE185 TTRQFLMSDK195 PLHLEASLDK205 EIYYHGEPIS 215 VNVHVTNNTN225 KTVKKIKISV235 RQYADICLFN245 TAQYKCPVAM255 EEADDTVAPS 265 STFCKVYTLT275 PFLANNREKR285 GLALDGKLKH295 EDTNLASSTL305 LREGANREIL 315 GIIVSYKVKV325 KLVVSRGGDV335 AVELPFTLMH345 PKPKEEPPHR355 EVPEN |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular basis of Beta-arrestin coupling to formoterol-bound Beta(1)-adrenoceptor. Nature. 2020 Jul;583(7818):862-866. | ||||
| REF 2 | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron. 2022 Oct 5;110(19):3154-3167.e7. | ||||
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