Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39996 | Target Info | |||
| Target Name | Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) | ||||
| Synonyms | EHMT1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | EHMT1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Ademetionine | Ligand Info | |||||
| Structure Description | Crystal structure of catalytic domain of GLP with MS012 | PDB:5TTG | ||||
| Method | X-ray diffraction | Resolution | 1.66 Å | Mutation | No | [1] |
| PDB Sequence |
VERIVSRDIA
1015 RGYERIPIPC1025 VNAVDSEPCP1035 SNYKYVSQNC1045 VTSPMNIDRN1055 ITHLQYCVCI 1065 DDCSSSNCMC1075 GQLSMRCWYD1085 KDGRLLPEFN1095 MAEPPLIFEC1105 NHACSCWRNC 1115 RNRVVQNGLR1125 ARLQLYRTRD1135 MGWGVRSLQD1145 IPPGTFVCEY1155 VGELISDSEA 1165 DVREEDSYLF1175 DLDNDGEVYC1186 IDARFYGNVS1196 RFINHHCEPN1206 LVPVRVFMAH 1216 QDLRFPRIAF1226 FSTRLIEAGE1236 QLGFDYGERF1246 WDIKGKLFSC1256 RCGSPKCRHS 1266
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ARG1132
4.753
MET1136
2.699
GLY1137
3.696
TRP1138
2.805
SER1172
3.249
TYR1173
2.738
ARG1197
3.224
PHE1198
3.636
ILE1199
3.757
ASN1200
2.889
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: MS012 | Ligand Info | |||||
| Structure Description | Crystal structure of catalytic domain of GLP with MS012 | PDB:5TTG | ||||
| Method | X-ray diffraction | Resolution | 1.66 Å | Mutation | No | [1] |
| PDB Sequence |
VERIVSRDIA
1015 RGYERIPIPC1025 VNAVDSEPCP1035 SNYKYVSQNC1045 VTSPMNIDRN1055 ITHLQYCVCI 1065 DDCSSSNCMC1075 GQLSMRCWYD1085 KDGRLLPEFN1095 MAEPPLIFEC1105 NHACSCWRNC 1115 RNRVVQNGLR1125 ARLQLYRTRD1135 MGWGVRSLQD1145 IPPGTFVCEY1155 VGELISDSEA 1165 DVREEDSYLF1175 DLDNDGEVYC1186 IDARFYGNVS1196 RFINHHCEPN1206 LVPVRVFMAH 1216 QDLRFPRIAF1226 FSTRLIEAGE1236 QLGFDYGERF1246 WDIKGKLFSC1256 RCGSPKCRHS 1266
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| Ligand Name: BIX-01294 | Ligand Info | |||||
| Structure Description | G9a-like protein lysine methyltransferase inhibition by BIX-01294 | PDB:3FPD | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [2] |
| PDB Sequence |
VERIVSRDIA
984 RGYERIPIPC994 VNAVDSEPCP1004 SNYKYVSQNC1014 VTSPMNIDRN1024 ITHLQYCVCI 1034 DDCSSSNCMC1044 GQLSMRCWYD1054 KDGRLLPEFN1064 MAEPPLIFEC1074 NHACSCWRNC 1084 RNRVVQNGLR1094 ARLQLYRTRD1104 MGWGVRSLQD1114 IPPGTFVCEY1124 VGELISDSEA 1134 DVREEDSYLF1144 DLDNKDGEVY1154 CIDARFYGNV1164 SRFINHHCEP1174 NLVPVRVFMA 1184 HQDLRFPRIA1194 FFSTRLIEAG1204 EQLGFDYGER1214 FWDIKGKLFS1224 CRCGSPKCRH 1234 S
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Q4A or .Q4A2 or .Q4A3 or :3Q4A;style chemicals stick;color identity;select .A:1131 or .A:1134 or .A:1135 or .A:1137 or .A:1138 or .A:1140 or .A:1141 or .A:1143 or .A:1144 or .A:1145 or .A:1153 or .A:1155 or .A:1211 or .A:1214 or .A:1215 or .A:1218 or .A:1219; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: Sinefungin | Ligand Info | |||||
| Structure Description | GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me0 peptide | PDB:3SW9 | ||||
| Method | X-ray diffraction | Resolution | 3.05 Å | Mutation | No | [3] |
| PDB Sequence |
VERIVSRDIA
984 RGYERIPIPC994 VNAVDSEPCP1004 SNYKYVSQNC1014 VTSPMNIDRN1024 ITHLQYCVCI 1034 DDCSSSNCMC1044 GQLSMRCWYD1054 KDGRLLPEFN1064 MAEPPLIFEC1074 NHACSCWRNC 1084 RNRVVQNGLR1094 ARLQLYRTRD1104 MGWGVRSLQD1114 IPPGTFVCEY1124 VGELISDSEA 1134 DVREEDSYLF1144 DLDNKDGEVY1154 CIDARFYGNV1164 SRFINHHCEP1174 NLVPVRVFMA 1184 HQDLRFPRIA1194 FFSTRLIEAG1204 EQLGFDYGER1214 FWDIKGKLFS1224 CRCGSPKCRH 1234 S
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SFG or .SFG2 or .SFG3 or :3SFG;style chemicals stick;color identity;select .A:1101 or .A:1105 or .A:1106 or .A:1107 or .A:1141 or .A:1142 or .A:1166 or .A:1167 or .A:1168 or .A:1169 or .A:1170 or .A:1211 or .A:1215 or .A:1216 or .A:1219 or .A:1223 or .A:1224 or .A:1225 or .A:1226 or .A:1227; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG1101
4.930
MET1105
2.836
GLY1106
4.114
TRP1107
3.047
SER1141
3.198
TYR1142
2.531
ARG1166
2.605
PHE1167
3.297
ILE1168
3.831
ASN1169
2.857
|
|||||
| Ligand Name: N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine | Ligand Info | |||||
| Structure Description | Crystal structure of catalytic domain of GLP with MS0105 | PDB:5V9J | ||||
| Method | X-ray diffraction | Resolution | 1.74 Å | Mutation | No | [4] |
| PDB Sequence |
VERIVSRDIA
1015 RGYERIPIPC1025 VNAVDSEPCP1035 SNYKYVSQNC1045 VTSPMNIDRN1055 ITHLQYCVCI 1065 DDCSSSNCMC1075 GQLSMRCWYD1085 KDGRLLPEFN1095 MAEPPLIFEC1105 NHACSCWRNC 1115 RNRVVQNGLR1125 ARLQLYRTRD1135 MGWGVRSLQD1145 IPPGTFVCEY1155 VGELISDSEA 1165 DVREEDSYLF1175 DLDGEVYCID1188 ARFYGNVSRF1198 INHHCEPNLV1208 PVRVFMAHQD 1218 LRFPRIAFFS1228 TRLIEAGEQL1238 GFDYGERFWD1248 IKGKLFSCRC1258 GSPKCRHS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .90P or .90P2 or .90P3 or :390P;style chemicals stick;color identity;select .A:1162 or .A:1165 or .A:1166 or .A:1167 or .A:1168 or .A:1171 or .A:1172 or .A:1174 or .A:1175 or .A:1176 or .A:1178 or .A:1184 or .A:1185 or .A:1186 or .A:1242 or .A:1245 or .A:1246 or .A:1249 or .A:1250; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP1162
3.685
ALA1165
3.200
ASP1166
3.193
VAL1167
4.474
ARG1168
3.532
ASP1171
3.045
SER1172
4.651
LEU1174
3.397
PHE1175
4.699
ASP1176
2.845
|
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| Ligand Name: N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)prop-2-enamide | Ligand Info | |||||
| Structure Description | Structure of human GLP SET-domain (EHMT1) in complex with covalent inhibitor (Compound 1) | PDB:7T7M | ||||
| Method | X-ray diffraction | Resolution | 2.85 Å | Mutation | No | [5] |
| PDB Sequence |
VERIVSRDIA
1015 RGYERIPIPC1025 VNAVDSEPCP1035 SNYKYVSQNC1045 VTSPMNIDRN1055 ITHLQYCVCI 1065 DDCSSSNCMC1075 GQLSMRCWYD1085 KDGRLLPEFN1095 MAEPPLIFEC1105 NHACSCWRNC 1115 RNRVVQNGLR1125 ARLQLYRTRD1135 MGWGVRSLQD1145 IPPGTFVCEY1155 VGELISDSEA 1165 DVREEDSYLF1175 DLDNKGEVYC1186 IDARFYGNVS1196 RFINHHCEPN1206 LVPVRVFMAH 1216 QDLRFPRIAF1226 FSTRLIEAGE1236 QLGFDYGERF1246 WDIKGKLFSC1256 RCGSPKCRHS 1266
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G4R or .G4R2 or .G4R3 or :3G4R;style chemicals stick;color identity;select .A:1155 or .A:1162 or .A:1165 or .A:1166 or .A:1168 or .A:1171 or .A:1172 or .A:1173 or .A:1174 or .A:1175 or .A:1176 or .A:1184 or .A:1186 or .A:1240 or .A:1242 or .A:1245 or .A:1246 or .A:1249 or .A:1250; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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TYR1155
3.694
ASP1162
3.349
ALA1165
3.309
ASP1166
3.228
ARG1168
4.432
ASP1171
3.087
SER1172
3.205
TYR1173
4.641
LEU1174
2.718
PHE1175
3.632
|
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| Ligand Name: 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine | Ligand Info | |||||
| Structure Description | Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 | PDB:3MO5 | ||||
| Method | X-ray diffraction | Resolution | 2.14 Å | Mutation | No | [6] |
| PDB Sequence |
IVSRDIARGY
987 ERIPIPCVNA997 VDSEPCPSNY1007 KYVSQNCVTS1017 PMNIDRNITH1027 LQYCVCIDDC 1037 SSSNCMCGQL1047 SMRCWYDKDG1057 RLLPEFNMAE1067 PPLIFECNHA1077 CSCWRNCRNR 1087 VVQNGLRARL1097 QLYRTRDMGW1107 GVRSLQDIPP1117 GTFVCEYVGE1127 LISDSEADVR 1137 EEDSYLFDLD1147 GEVYCIDARF1160 YGNVSRFINH1170 HCEPNLVPVR1180 VFMAHQDLRF 1190 PRIAFFSTRL1200 IEAGEQLGFD1210 YGERFWDIKG1220 KLFSCRCGSP1230 KCRHS |
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .E72 or .E722 or .E723 or :3E72;style chemicals stick;color identity;select .A:1124 or .A:1131 or .A:1134 or .A:1135 or .A:1136 or .A:1137 or .A:1138 or .A:1140 or .A:1141 or .A:1142 or .A:1143 or .A:1144 or .A:1145 or .A:1155 or .A:1209 or .A:1211 or .A:1214 or .A:1215 or .A:1218 or .A:1219; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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TYR1124
3.571
ASP1131
2.791
ALA1134
3.223
ASP1135
3.121
VAL1136
4.243
ARG1137
3.400
GLU1138
4.482
ASP1140
2.777
SER1141
3.003
TYR1142
3.876
|
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| Ligand Name: 7-[(5-Aminopentyl)oxy]-N~4~-(1-Benzylpiperidin-4-Yl)-N~2~-[3-(Dimethylamino)propyl]-6-Methoxyquinazoline-2,4-Diamine | Ligand Info | |||||
| Structure Description | human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 | PDB:3MO2 | ||||
| Method | X-ray diffraction | Resolution | 2.49 Å | Mutation | No | [6] |
| PDB Sequence |
IVSRDIARGY
987 ERIPIPCVNA997 VDSEPCPSNY1007 KYVSQNCVTS1017 PMNIDRNITH1027 LQYCVCIDDC 1037 SSSNCMCGQL1047 SMRCWYDKDG1057 RLLPEFNMAE1067 PPLIFECNHA1077 CSCWRNCRNR 1087 VVQNGLRARL1097 QLYRTRDMGW1107 GVRSLQDIPP1117 GTFVCEYVGE1127 LISDSEADVR 1137 EEDSYLFDLD1147 GEVYCIDARF1160 YGNVSRFINH1170 HCEPNLVPVR1180 VFMAHQDLRF 1190 PRIAFFSTRL1200 IEAGEQLGFD1210 YGERFWDIKG1220 KLFSCRCGSP1230 KCRHS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .E67 or .E672 or .E673 or :3E67;style chemicals stick;color identity;select .A:1124 or .A:1131 or .A:1134 or .A:1135 or .A:1136 or .A:1137 or .A:1138 or .A:1140 or .A:1141 or .A:1142 or .A:1143 or .A:1144 or .A:1145 or .A:1155 or .A:1209 or .A:1211 or .A:1212 or .A:1214 or .A:1215 or .A:1218 or .A:1219; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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TYR1124
4.252
ASP1131
3.002
ALA1134
3.610
ASP1135
2.992
VAL1136
4.226
ARG1137
3.589
GLU1138
3.549
ASP1140
2.893
SER1141
3.360
TYR1142
4.709
LEU1143
3.087
|
|||||
| Ligand Name: N~4~-(1-Benzylpiperidin-4-Yl)-N~2~-[3-(Dimethylamino)propyl]-6,7-Dimethoxyquinazoline-2,4-Diamine | Ligand Info | |||||
| Structure Description | Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11 | PDB:3MO0 | ||||
| Method | X-ray diffraction | Resolution | 2.78 Å | Mutation | No | [6] |
| PDB Sequence |
RIVSRDIARG
986 YERIPIPCVN996 AVDSEPCPSN1006 YKYVSQNCVT1016 SITHLQYCVC1033 IDDCSSSNCM 1043 CGQLSMRCWY1053 DKDGRLLPEF1063 NMAEPPLIFE1073 CNHACSCWRN1083 CRNRVVQNGL 1093 RARLQLYRTR1103 DMGWGVRSLQ1113 DIPPGTFVCE1123 YVGELISDSE1133 ADVREEDSYL 1143 FDLDNKDGEV1153 YCIDARFYGN1163 VSRFINHHCE1173 PNLVPVRVFM1183 AHQDLRFPRI 1193 AFFSTRLIEA1203 GEQLGFDYGE1213 RFWDIKGKLF1223 SCRCGSPKCR1233 H |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .E11 or .E112 or .E113 or :3E11;style chemicals stick;color identity;select .A:1131 or .A:1132 or .A:1134 or .A:1135 or .A:1136 or .A:1137 or .A:1138 or .A:1140 or .A:1141 or .A:1143 or .A:1145 or .A:1153 or .A:1155 or .A:1214 or .A:1215 or .A:1218 or .A:1219; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-cyclohexyl-7-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-8-[3-(pyrrolidin-1-yl)propoxy]-3H-1,4-benzodiazepin-5-amine | Ligand Info | |||||
| Structure Description | GLP Methyltransferase with Inhibitor EML741-P212121 Crystal Form | PDB:6MBO | ||||
| Method | X-ray diffraction | Resolution | 1.59 Å | Mutation | No | [7] |
| PDB Sequence |
VERIVSRDIA
984 RGYERIPIPC994 VNAVDSEPCP1004 SNYKYVSQNC1014 VTSPMNIDRN1024 ITHLQYCVCI 1034 DDCSSSNCMC1044 GQLSMRCWYD1054 KDGRLLPEFN1064 MAEPPLIFEC1074 NHACSCWRNC 1084 RNRVVQNGLR1094 ARLQLYRTRD1104 MGWGVRSLQD1114 IPPGTFVCEY1124 VGELISDSEA 1134 DVREEDSYLF1144 DLDNKDGEVY1154 CIDARFYGNV1164 SRFINHHCEP1174 NLVPVRVFMA 1184 HQDLRFPRIA1194 FFSTRLIEAG1204 EQLGFDYGER1214 FWDIKGKLFS1224 CRCGSPKCRH 1234 S
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .JDG or .JDG2 or .JDG3 or :3JDG;style chemicals stick;color identity;select .A:1025 or .A:1026 or .A:1027 or .A:1028 or .A:1030 or .A:1077 or .A:1124 or .A:1130 or .A:1131 or .A:1134 or .A:1135 or .A:1136 or .A:1137 or .A:1138 or .A:1140 or .A:1141 or .A:1142 or .A:1143 or .A:1144 or .A:1145 or .A:1153 or .A:1154 or .A:1155 or .A:1209 or .A:1211 or .A:1214 or .A:1215 or .A:1218 or .A:1219; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ILE1025
4.238
THR1026
2.968
HIS1027
4.988
LEU1028
4.822
TYR1030
3.521
ALA1077
3.729
TYR1124
3.487
SER1130
4.848
ASP1131
3.838
ALA1134
3.436
ASP1135
3.189
VAL1136
4.453
ARG1137
3.214
GLU1138
4.582
ASP1140
2.725
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: N~2~-Cyclopentyl-6,7-Dimethoxy-N~2~-Methyl-N~4~-(1-Methylpiperidin-4-Yl)quinazoline-2,4-Diamine | Ligand Info | |||||
| Structure Description | Structure of human GLP SET-domain (EHMT1) in complex with inhibitor 17 | PDB:5VSF | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [8] |
| PDB Sequence |
VERIVSRDIA
1015 RGYERIPIPC1025 VNAVDSEPCP1035 SNYKYVSQNC1045 VTSPMNIDRN1055 ITHLQYCVCI 1065 DDCSSSNCMC1075 GQLSMRCWYD1085 KDGRLLPEFN1095 MAEPPLIFEC1105 NHACSCWRNC 1115 RNRVVQNGLR1125 ARLQLYRTRD1135 MGWGVRSLQD1145 IPPGTFVCEY1155 VGELISDSEA 1165 DVREEDSYLF1175 DLDNKDGEVY1185 CIDARFYGNV1195 SRFINHHCEP1205 NLVPVRVFMA 1215 HQDLRFPRIA1225 FFSTRLIEAG1235 EQLGFDYGER1245 FWDIKGKLFS1255 CRCGSPKCRH 1265 S
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9HG or .9HG2 or .9HG3 or :39HG;style chemicals stick;color identity;select .A:1162 or .A:1165 or .A:1166 or .A:1167 or .A:1168 or .A:1169 or .A:1171 or .A:1172 or .A:1174 or .A:1175 or .A:1176 or .A:1184 or .A:1186 or .A:1242 or .A:1245 or .A:1246 or .A:1249 or .A:1250; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 6,7-Dimethoxy-N~2~-Methyl-N~4~-(1-Methylpiperidin-4-Yl)-N~2~-Propylquinazoline-2,4-Diamine | Ligand Info | |||||
| Structure Description | Structure of human GLP SET-domain (EHMT1) in complex with inhibitor 13 | PDB:5VSD | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [8] |
| PDB Sequence |
VERIVSRDIA
1015 RGYERIPIPC1025 VNAVDSEPCP1035 SNYKYVSQNC1045 VTSPMNIDRN1055 ITHLQYCVCI 1065 DDCSSSNCMC1075 GQLSMRCWYD1085 KDGRLLPEFN1095 MAEPPLIFEC1105 NHACSCWRNC 1115 RNRVVQNGLR1125 ARLQLYRTRD1135 MGWGVRSLQD1145 IPPGTFVCEY1155 VGELISDSEA 1165 DVREEDSYLF1175 DLDEVYCIDA1189 RFYGNVSRFI1199 NHHCEPNLVP1209 VRVFMAHQDL 1219 RFPRIAFFST1229 RLIEAGEQLG1239 FDYGERFWDI1249 KGKLFSCRCG1259 SPKCRHS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9HJ or .9HJ2 or .9HJ3 or :39HJ;style chemicals stick;color identity;select .A:1162 or .A:1165 or .A:1166 or .A:1167 or .A:1168 or .A:1171 or .A:1172 or .A:1174 or .A:1175 or .A:1176 or .A:1184 or .A:1185 or .A:1186 or .A:1242 or .A:1245 or .A:1246 or .A:1249 or .A:1250; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 6,7-Dimethoxy-N-(1-Methylpiperidin-4-Yl)-2-(Morpholin-4-Yl)quinazolin-4-Amine | Ligand Info | |||||
| Structure Description | Structure of human GLP SET-domain (EHMT1) in complex with inhibitor MS0124 | PDB:5TUZ | ||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [1] |
| PDB Sequence |
VERIVSRDIA
1015 RGYERIPIPC1025 VNAVDSEPCP1035 SNYKYVSQNC1045 VTSPMNIDRN1055 ITHLQYCVCI 1065 DDCSSSNCMC1075 GQLSMRCWYD1085 KDGRLLPEFN1095 MAEPPLIFEC1105 NHACSCWRNC 1115 RNRVVQNGLR1125 ARLQLYRTRD1135 MGWGVRSLQD1145 IPPGTFVCEY1155 VGELISDSEA 1165 DVREEDSYLF1175 DLDNGEVYCI1187 DARFYGNVSR1197 FINHHCEPNL1207 VPVRVFMAHQ 1217 DLRFPRIAFF1227 STRLIEAGEQ1237 LGFDYGERFW1247 DIKGKLFSCR1257 CGSPKCRHS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7L6 or .7L62 or .7L63 or :37L6;style chemicals stick;color identity;select .A:1162 or .A:1165 or .A:1166 or .A:1167 or .A:1168 or .A:1171 or .A:1174 or .A:1175 or .A:1176 or .A:1184 or .A:1186 or .A:1242 or .A:1245 or .A:1246 or .A:1249 or .A:1250; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. J Med Chem. 2017 Mar 9;60(5):1876-1891. | ||||
| REF 2 | Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol. 2009 Mar;16(3):312-7. | ||||
| REF 3 | MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun. 2011 Nov 15;2:533. | ||||
| REF 4 | Crystal structure of catalytic domain of GLP with MS0105 | ||||
| REF 5 | Discovery of the First-in-Class G9a/GLP Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10506-10522. | ||||
| REF 6 | Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol. 2010 Jul 2;400(1):1-7. | ||||
| REF 7 | Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure. J Med Chem. 2019 Mar 14;62(5):2666-2689. | ||||
| REF 8 | Structure-activity relationship studies of G9a-like protein (GLP) inhibitors. Bioorg Med Chem. 2017 Aug 15;25(16):4414-4423. | ||||
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