Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06PPL
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| Former ID |
DIB018984
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| Drug Name |
BIX-01294
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| Synonyms |
BIX01294; BIX 01294
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65; ICD-10: C50, C79.51] | Preclinical | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C28H38N6O2
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| Canonical SMILES |
CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC
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| InChI |
1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)
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| InChIKey |
OSXFATOLZGZLSK-UHFFFAOYSA-N
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| CAS Number |
CAS 935693-62-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
57244525, 57571250, 87352006, 90341493, 96160396, 99431665, 103701282, 104154389, 123105088, 124896674, 124896675, 125434215, 141202742, 152133948, 152258258, 160647094, 162256579, 163596611, 163685927, 163981435, 172918692, 177748384, 178103593, 185998808, 187071876, 223709101, 226698948, 244708051, 252450753, 252552000
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| ChEBI ID |
CHEBI:93986
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) | Target Info | Inhibitor | [2] |
| Histone-lysine N-methyltransferase EHMT2 (EHMT2) | Target Info | Inhibitor | [2] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. | |||
| REF 2 | Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007 Feb 9;25(3):473-81. | |||
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