Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T37735 | Target Info | |||
Target Name | Glutamate decarboxylase (GLUL) | ||||
Synonyms | Glutamateammonia ligase | ||||
Target Type | Discontinued Target | ||||
Gene Name | GLUL | ||||
Biochemical Class | Carbon-nitrogen ligase | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: adenosine diphosphate | Ligand Info | |||||
Structure Description | Crystal structure of human glutamine synthetase in complex with ADP and phosphate | PDB:2OJW | ||||
Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [1] |
PDB Sequence |
YFQSMASSHL
9 NKGIKQVYMS19 LPQGEKVQAM29 YIWIDGTGEG39 LRCKTRTLDS49 EPKCVEELPE 59 WNFDGSSTLQ69 SEGSNSDMYL79 VPAAMFRDPF89 RKDPNKLVLC99 EVFKYNRRPA 109 ETNLRHTCKR119 IMDMVSNQHP129 WFGMEQEYTL139 MGDGHPFGWP150 SNGFPGPQGP 160 YYCGVGADRA170 YGRDIVEAHY180 RACLYAGVKI190 AGTNAEVMPA200 QWEFQIGPCE 210 GISMGDHLWV220 ARFILHRVCE230 DFGVIATFDP240 KPIPGNWNGA250 GCHTNFSTKA 260 MREENGLKYI270 EEAIEKLSKR280 HQYHIRAYDP290 KGGLDNARRL300 TSNINDFSAG 315 VANRSASIRI325 PRTVGQEKKG335 YFEDRRPSAN345 CDPFSVTEAL355 IRTCLLNETG 365
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TRP130
3.461
PHE131
3.950
GLY132
3.547
MET133
4.180
GLU134
3.049
ALA191
3.738
ASN194
4.806
GLU203
3.105
GLN205
3.209
ILE206
3.709
GLY207
3.446
PRO208
3.371
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Ligand Name: L-Methionine-S-sulfoximine phosphate | Ligand Info | |||||
Structure Description | Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate | PDB:2QC8 | ||||
Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
PDB Sequence |
NKGIKQVYMS
19 LPQGEKVQAM29 YIWIDGTGEG39 LRCKTRTLDS49 EPKCVEELPE59 WNFDGSSTLQ 69 SEGSNSDMYL79 VPAAMFRDPF89 RKDPNKLVLC99 EVFKYNRRPA109 ETNLRHTCKR 119 IMDMVSNQHP129 WFGMEQEYTL139 MGTDGHPFGW149 PSNGFPGPQG159 PYYCGVGADR 169 AYGRDIVEAH179 YRACLYAGVK189 IAGTNAEVMP199 AQWEFQIGPC209 EGISMGDHLW 219 VARFILHRVC229 EDFGVIATFD239 PKPIPGNWNG249 AGCHTNFSTK259 AMREENGLKY 269 IEEAIEKLSK279 RHQYHIRAYD289 PKGGLDNARR299 LTGFHETSNI309 NDFSAGVANR 319 SASIRIPRTV329 GQEKKGYFED339 RRPSANCDPF349 SVTEALIRTC359 LLNETG |
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GLU134
2.829
GLU136
2.707
TYR162
3.848
ASN194
4.932
GLU196
2.997
VAL197
3.975
GLN201
4.394
GLU203
3.105
ASN248
3.887
GLY249
2.664
ALA250
4.035
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References | Top | ||||
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REF 1 | Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design. J Mol Biol. 2008 Jan 4;375(1):217-28. |
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