Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T34405 Target Info
Target Name Fractalkine (CX3CL1)
Synonyms Small-inducible cytokine D1; Small inducible cytokine D1; SCYD1; Neurotactin; NTT; FKN; CX3C membrane-anchored chemokine; C-X3-C motif chemokine 1; A-152E5.2
Target Type Literature-reported Target
Gene Name CX3CL1
UniProt ID
X3CL1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cholesterol Ligand Info
Structure Description Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1 PDB:7XBX
Method Electron microscopy Resolution 3.40 Å Mutation Yes [1]
PDB Sequence
HHGVTKCNIT
11
CSKMTSKIPV
21
ALLIHYQQNQ
31
ASCCKRAIIL
41
ETRQHRLFCE
55

QWVKDAMQHL
65
DYIGDIVVFG
132
TVFLSIFYSV
142
IFAIGLVGNL
152
LVVFALTNSK
162

KPKSVTDIYL
172
LNLALSDLLF
182
VATLPFWTHY
192
LINEKGLHNA
202
MCKFTTAFFF
212

IGFFGSIFFL
222
TVISIDRYLA
232
IVLAANSMNN
242
RTVQHGVTIS
252
LGVWAAAILV
262

AAPQFMFTKQ
272
KENECCGDYP
282
EVLQEIWPVL
292
RNVETNFLGF
302
LLPLLIMSYC
312

YFRIIQTLFS
322
SKNHKKAKAI
332
KLILLVVIVF
342
FLFWTPYNVV
352
IFLETLKLYD
362

FFPSCDMRKD
372
LRLALSVTET
382
VAFSHCCLNP
392
LIYAFAGEKF
402
RRYLYHLY
Residue
Distance (Å)
ILE219
4.835
PHE220
2.632
THR223
2.689
VAL224
3.553
ILE227
4.019
HIS247
3.614
THR250
2.542
ILE251
2.623
GLY254
3.397
VAL255
3.623
ALA258
4.046
LEU300
3.502
Residue
Distance (Å)
LEU304
2.615
PRO305
2.762
LEU307
3.481
ILE308
3.962
SER310
2.850
TYR311
4.065
TYR313
4.593
PHE314
2.780
ILE317
2.986
PHE321
2.666
LEU336
4.589
Ligand Name: Pyroglutamic Acid Ligand Info
Structure Description Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1 PDB:4XT1
Method X-ray diffraction Resolution 2.89 Å Mutation Yes [2]
PDB Sequence
HHGVTKCAIT
11
CSKMTSKIPV
21
ALLIHYQQNQ
31
ASCGKRAIIL
41
ETRQHRLFCA
51

DPKEQWVKDA
61
MQHLDRQ
Residue
Distance (Å)
HIS2
1.330
HIS3
4.507
Residue
Distance (Å)
VAL5
3.860
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv. 2022 Jul;8(26):eabn8048.
REF 2 Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science. 2015 Mar 6;347(6226):1113-7.

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