Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32386 | Target Info | |||
| Target Name | Endocytic receptor Endo180 (MRC2) | ||||
| Synonyms | Urokinase-type plasminogen activator receptor-associated protein; Urokinase receptor-associated protein; UPARAP; UPAR-associated protein; Macrophage mannose receptor 2; KIAA0709; Endocytic receptor 180; ENDO180; CLEC13E; CD280; C-type mannose receptor 2; C-type lectin domain family 13 member E | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | MRC2 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 3,6,9,12,15,18,21,24-Octaoxahexacosan-1-OL | Ligand Info | |||||
| Structure Description | Structure of ligand binding region of uPARAP at pH 7.4 | PDB:5E4K | ||||
| Method | X-ray diffraction | Resolution | 2.58 Å | Mutation | Yes | [1] |
| PDB Sequence |
ALPEPNIFLI
46 FSHGLQGCLE56 AQGGQVRVTP66 ACNTSLPAQR76 WKWVSRNRLF86 NLGTMQCLGT 96 ASLGMYECDR114 EALNLRWHCR124 TLGDQLSLLL134 QWRIYGSEED166 LCALPYHEVY 176 TIQGNSHGKP186 CTIPFKYDNQ196 WFHGCTSTGR206 EDGHLWCATT216 QDYGKDERWG 226 FCPIKSNDCE236 TFWDKDQLTD246 SCYQFNFQST256 LSWREAWASC266 EQQGADLLSI 276 TEIHEQTYIN286 GLLTGYSSTL296 WIGLNDLDTS306 GGWQWSDNSP316 LKYLNWESDQ 326 PDNPSEENCG336 VIRTESSGGW346 QNRDCSIALP356 YVCKKKPVEC382 EPSWQPFQGH 392 CYRLQAEKRS402 WQESKKACLR412 GGGDLVSIHS422 MAELEFITKQ432 IKQEVEELWI 442 GLNDLKLQMN452 FEWSDGSLVS462 FTHWHPFEPN472 NFRDSLEDCV482 TIWGPEGRWN 492 DSPCNQSLPS502 ICKK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding. Biochem J. 2016 Aug 1;473(15):2359-68. | ||||
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