Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T21689 | Target Info | |||
| Target Name | Apolipoprotein E (APOE) | ||||
| Synonyms | ApoE; Apo-E | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | APOE | ||||
| Biochemical Class | Apolipoprotein | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 1-[5-Chloro-4'-(2-hydroxypropan-2-yl)[1,1'-biphenyl]-3-yl]cyclobutane-1-carboximidamide | Ligand Info | |||||
| Structure Description | Fragment-based Discovery of an apoE4 Stabilizer | PDB:6NCO | ||||
| Method | X-ray diffraction | Resolution | 1.71 Å | Mutation | Yes | [1] |
| PDB Sequence |
QRWELALGRF
33 WDYLRWVQTL43 SEQVQEELLS53 SQVTQELRAL63 MDETMKELKA73 YKSELEEQLT 83 PVAEETRARL93 SKELQAAQAR103 LGADMEDVRG113 RLVQYRGEVQ123 AMLGQSTEEL 133 RVRLASHLRK143 LRKRLLRDAD153 DLQKRLAVYQ163 A
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| Ligand Name: 1-(3-Chlorophenyl)cyclobutane-1-carboximidamide | Ligand Info | |||||
| Structure Description | Fragment-based Discovery of an apoE4 Stabilizer | PDB:6NCN | ||||
| Method | X-ray diffraction | Resolution | 1.82 Å | Mutation | Yes | [1] |
| PDB Sequence |
QRWELALGRF
33 WDYLRWVQTL43 SEQVQEELLS53 SQVTQELRAL63 MDETMKELKA73 YKSELEEQLT 83 PVAEETRARL93 SKELQAAQAR103 LGADMEDVRG113 RLVQYRGEVQ123 AMLGQSTEEL 133 RVRLASHLRK143 LRKRLLRDAD153 DLQKRLAVYQ163 A
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer. J Med Chem. 2019 Apr 25;62(8):4120-4130. | ||||
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