Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14065 | Target Info | |||
| Target Name | Integrin beta-7 (ITGB7) | ||||
| Synonyms | Gut homing receptor beta subunit | ||||
| Target Type | Successful Target | ||||
| Gene Name | ITGB7 | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Glutathione | Ligand Info | |||||
| Structure Description | Crystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide | PDB:2BRQ | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
PLYKSAITTT
785 INPR
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| Ligand Name: N-(2,6-Dichlorobenzoyl)-4-[1,6-Dimethyl-2-Oxo-4-(Trifluoromethyl)-1,2-Dihydropyridin-3-Yl]-L-Phenylalanine | Ligand Info | |||||
| Structure Description | crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376 | PDB:3V4V | ||||
| Method | X-ray diffraction | Resolution | 3.10 Å | Mutation | Yes | [2] |
| PDB Sequence |
RGQQEVLQDQ
90 PLSQGARGEG100 ATQLAPQRVR110 VTLRPGEPQQ120 LQVRFLRAEG130 YPVDLYYLMD 140 LSYSMKDDLE150 RVRQLGHALL160 VRLQEVTHSV170 RIGFGSFVDK180 TVLPFVSTVP 190 SKLRHPCPTR200 LERCQSPFSF210 HHVLSLTGDA220 QAFEREVGRQ230 SVSGNLDSPE 240 GGFDAILQAA250 LCQEQIGWRN260 VSRLLVFTSD270 DTFHTAGDGK280 LGGIFMPSDG 290 HCHLDSNGLY300 SRSTEFDYPS310 VGQVAQALSA320 ANIQPIFAVT330 SAALPVYQEL 340 SKLIPKSAVG350 ELSEDSSNVV360 QLIMDAYNSL370 SSTVTLEHSS380 LPPGVHISYE 390 SQCEGPEKRE400 GKAEDRGQCN410 HVRINQTVTF420 WVSLQATHCL430 PEPHLLRLRA 440 LGFSEELIVE450 LHTLC
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The molecular basis of filamin binding to integrins and competition with talin. Mol Cell. 2006 Feb 3;21(3):337-47. | ||||
| REF 2 | Structural specializations of Alpha(4)beta(7), an integrin that mediates rolling adhesion. J Cell Biol. 2012 Jan 9;196(1):131-46. | ||||
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