Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T11288 Target Info
Target Name Multidrug resistance-associated protein 1 (ABCC1)
Synonyms MRP1; MRP; Leukotriene C(4) transporter; LTC4 transporter; ATP-binding cassette sub-family C member 1
Target Type Successful Target
Gene Name ABCC1
Biochemical Class ABC transporter
UniProt ID
MRP1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Adenosine triphosphate Ligand Info
Structure Description Structure of the human Multidrug Resistance Protein 1 Nucleotide Binding Domain 1 PDB:2CBZ
Method X-ray diffraction Resolution 1.50 Å Mutation No [1]
PDB Sequence
NSITVRNATF
651
TWARSDPPTL
661
NGITFSIPEG
671
ALVAVVGQVG
681
CGKSSLLSAL
691

LAEMDKVEGH
701
VAIKGSVAYV
711
PQQAWIQNDS
721
LRENILFGCQ
731
LEEPYYRSVI
741

QACALLPDLE
751
ILPSGDRTEI
761
GEKGVNLSGG
771
QKQRVSLARA
781
VYSNADIYLF
791

DDPLSAVDAH
801
VGKHIFENVI
811
GPKGMLKNKT
821
RILVTHSMSY
831
LPQVDVIIVM
841

SGGKISEMGS
851
YQELLARDGA
861
FAEFLRTYAS
871
H
Residue
Distance (Å)
TRP653
3.271
THR660
3.691
GLN679
4.275
VAL680
3.286
GLY681
3.108
CYS682
3.276
Residue
Distance (Å)
GLY683
3.040
LYS684
2.704
SER685
2.836
SER686
2.686
GLN713
2.964
References  Top
REF 1 Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site. J Mol Biol. 2006 Jun 16;359(4):940-9.

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