Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T10586 | Target Info | |||
| Target Name | Lysozyme (LYZ) | ||||
| Synonyms | Lysozyme C; LYZ; 1,4betaNacetylmuramidase C | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | LYZ | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Acetylcysteine | Ligand Info | |||||
| Structure Description | MUTANT HUMAN LYSOZYME C77A | PDB:207L | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
KVFERCELAR
10 TLKRLGMDGY20 RGISLANWMC30 LAKWESGYNT40 RATNYNAGDR50 STDYGIFQIN 60 SRYWCNDGKT70 PGAVNAAHLS80 CSALLQDNIA90 DAVACAKRVV100 RDPQGIRAWV 110 AWRNRCQNRD120 VRQYVQGCGV130
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| Ligand Name: Glutathione | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF A GLUTATHIONYLATED HUMAN LYSOZYME: A FOLDING INTERMEDIATE MIMIC IN THE FORMATION OF A DISULFIDE BOND | PDB:1HNL | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [2] |
| PDB Sequence |
KVFERCELAR
10 TLKRLGMDGY20 RGISLANWMC30 LAKWESGYNT40 RATNYNAGDR50 STDYGIFQIN 60 SRYWCNDGKT70 PGAVNAAHLS80 CSALLQDNIA90 DAVACAKRVV100 RDPQGIRAWV 110 AWRNRCQNRD120 VRQYVQGCGV130
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| Ligand Name: 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Lysozyme Complexed with N-Acetyl-alpha-D-Glucosamine | PDB:7XF7 | ||||
| Method | X-ray diffraction | Resolution | 1.55 Å | Mutation | No | [3] |
| PDB Sequence |
KVFERCELAR
28 TLKRLGMDGY38 RGISLANWMC48 LAKWESGYNT58 RATNYNAGDR68 STDYGIFQIN 78 SRYWCNDGKT88 PGAVNACHLS98 CSALLQDNIA108 DAVACAKRVV118 RDPQGIRAWV 128 AWRNRCQNRD138 VRQYVQGCGV148
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NDG or .NDG2 or .NDG3 or :3NDG;style chemicals stick;color identity;select .A:62 or .A:64 or .A:67 or .A:71 or .A:76 or .A:77 or .A:78 or .A:80 or .A:81 or .A:82 or .A:117 or .A:122 or .A:126 or .A:127 or .A:128 or .A:129; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: R-1,2-Propanediol | Ligand Info | |||||
| Structure Description | HUMAN LYSOZYME WITH MAN-B1,4-GLCNAC COVALENTLY ATTACHED TO ASP53 | PDB:1REM | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [4] |
| PDB Sequence |
KVFERCELAR
10 TLKRLGMDGY20 RGISLANWMC30 LAKWESGYNT40 RATNYNAGDR50 STDYGIFQIN 60 SRYWCNDGKT70 PGAVNACHLS80 CSALLQDNIA90 DAVACAKRVV100 RDPQGIRAWV 110 AWRNRCQNRD120 VRQYVQGCGV130
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PGR or .PGR2 or .PGR3 or :3PGR;style chemicals stick;color identity;select .A:46 or .A:53 or .A:58 or .A:60 or .A:108; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A role of PDI in the reductive cleavage of mixed disulfides. J Biochem. 1996 Sep;120(3):525-30. | ||||
| REF 2 | Structure of a glutathionylated human lysozyme: a folding intermediate mimic in the formation of a disulfide bond. Acta Crystallogr D Biol Crystallogr. 1995 Sep 1;51(Pt 5):619-25. | ||||
| REF 3 | Crystal Structure of Human Lysozyme Complexed with N-Acetyl-alpha-d-glucosamine.. doi:10.3390/app12094363. | ||||
| REF 4 | X-ray structure of human lysozyme labelled with 2',3'-epoxypropyl beta-glycoside of man-beta1,4-GlcNAc. Structural change and recognition specificity at subsite B. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):834-43. | ||||
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