Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07394 | Target Info | |||
| Target Name | Notch-1 receptor (NOTCH1) | ||||
| Synonyms | hN1; Translocationassociated notch protein TAN1; Translocation-associated notch protein TAN-1; TAN1; Notch 1 intracellular domain; Notch 1; Neurogenic locus notch homolog protein 1; NICD | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NOTCH1 | ||||
| Biochemical Class | Notch protein | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Uridine-5'-Diphosphate | Ligand Info | |||||
| Structure Description | human POGLUT1 in complex with Notch1 EGF12 and UDP | PDB:5L0R | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [1] |
| PDB Sequence |
DVNECVSNPC
461 QNDATCLDQI471 GEFQCICMPG481 YEGVHCEVNT491
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: alpha-L-Fucose | Ligand Info | |||||
| Structure Description | Human Notch1 EGF domains 11-13 mutant fucosylated at T466 | PDB:4CUD | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [2] |
| PDB Sequence |
DVDECSLGAN
421 PCEHAGKCIN431 TLGSFECQCL441 QGYTGPRCEI451 DVNECVSNPC461 QNDATCLDQI 471 GEFQCICMPG481 YEGVHCEVNT491 DECASSPCLH501 NGRCLDKINE511 FQCECPTGFT 521 GHLCQVDLHH531 IL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1). Nat Commun. 2017 Aug 4;8(1):185. | ||||
| REF 2 | Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7290-5. | ||||
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