Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T07394 Target Info
Target Name Notch-1 receptor (NOTCH1)
Synonyms hN1; Translocationassociated notch protein TAN1; Translocation-associated notch protein TAN-1; TAN1; Notch 1 intracellular domain; Notch 1; Neurogenic locus notch homolog protein 1; NICD
Target Type Clinical trial Target
Gene Name NOTCH1
Biochemical Class Notch protein
UniProt ID
NOTC1_HUMAN
Ligand General Information  Top
Ligand Name Uridine-5'-Diphosphate Ligand Info
Canonical SMILES C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
InChI 1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKey XCCTYIAWTASOJW-XVFCMESISA-N
PubChem Compound ID 6031
Drug Binding Sites of Target  Top
PDB ID: 5L0R      human POGLUT1 in complex with Notch1 EGF12 and UDP
Method X-ray diffraction Resolution 1.50 Å Mutation No [1]
PDB Sequence
DVNECVSNPC
461
QNDATCLDQI
471
GEFQCICMPG
481
YEGVHCEVNT
491
Residue
Distance (Å)
VAL457
4.876
Residue
Distance (Å)
SER458
4.882
PDB ID: 5UB5      human POGLUT1 in complex with human Notch1 EGF12 S458T mutant and UDP
Method X-ray diffraction Resolution 2.09 Å Mutation Yes [1]
PDB Sequence
DVNECVTNPC
461
QNDATCLDQI
471
GEFQCICMPG
481
YEGVHCEVNT
491
Residue
Distance (Å)
ASN459
3.687
Residue
Distance (Å)
References  Top
REF 1 Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1). Nat Commun. 2017 Aug 4;8(1):185.

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