Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T06525 Target Info
Target Name Rac family small GTPase 3 (RAC3)
Synonyms p21-Rac3; Ras-related C3 botulinum toxin substrate 3
Target Type Literature-reported Target
Gene Name RAC3
UniProt ID
RAC3_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Guanosine-5'-Diphosphate Ligand Info
Structure Description CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP PDB:2C2H
Method X-ray diffraction Resolution 1.85 Å Mutation No [1]
PDB Sequence
AIKCVVVGDG
12
AVGKTCLLIS
22
YTTNAFPGDN
39
YSANVMVDGK
49
PVNLGLWDTA
59

GQEDYDRLRP
69
LSYPQTDVFL
79
ICFSLVSPAS
89
FENVRAKWYP
99
EVRHHCPHTP
109

ILLVGTKLDL
119
RDDKDTIERL
129
RDKKLAPITY
139
PQGLAMAREI
149
GSVKYLECSA
159

LTQRGLKTVF
169
DEAIRAVL
Residue
Distance (Å)
ASP11
3.860
GLY12
3.897
ALA13
2.811
VAL14
3.330
GLY15
3.021
LYS16
2.700
THR17
2.919
CYS18
2.768
LEU19
4.880
PHE28
3.427
ASP57
4.796
PRO99
3.039
GLU100
3.452
HIS103
2.948
HIS104
2.871
Residue
Distance (Å)
PRO106
3.449
HIS107
2.912
LYS116
3.134
LEU117
3.759
ASP118
2.717
LEU119
3.491
ARG120
3.263
TYR139
3.337
PRO140
4.307
GLU156
2.654
SER158
3.483
ALA159
2.935
LEU160
3.157
ARG163
3.122
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: Phosphomethylphosphonic Acid Guanylate Ester Ligand Info
Structure Description Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1) PDB:2QME
Method X-ray diffraction Resolution 1.75 Å Mutation No [2]
PDB Sequence
MQAIKCVVVG
10
DGAVGKTCLL
20
ISYTTNAFPG
30
EYIPTVFDNY
40
SANVMVDGKP
50

VNLGLWDTAG
60
QEDYDRLRPL
70
SYPQTDVFLI
80
CFSLVSPASF
90
ENVRAKWYPE
100

VRHHCPHTPI
110
LLVGTKLDLR
120
DDKDTIERLR
130
DKKLAPITYP
140
QGLAMAREIG
150

SVKYLECSAL
160
TQRGLKTVFD
170
EAIRAVLG
Residue
Distance (Å)
GLY10
4.757
ASP11
3.840
GLY12
3.944
ALA13
3.632
VAL14
3.424
GLY15
3.084
LYS16
2.715
THR17
2.969
CYS18
2.820
LEU19
4.928
PHE28
3.520
PRO29
4.722
GLU31
4.984
TYR32
3.659
Residue
Distance (Å)
ILE33
4.418
PRO34
3.284
THR35
2.771
ASP57
4.823
THR58
4.158
ALA59
3.900
GLY60
2.780
GLN61
4.510
LYS116
3.037
ASP118
2.802
LEU119
3.478
SER158
3.500
ALA159
2.918
LEU160
3.239
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: Phosphoaminophosphonic acid-guanylate ester Ligand Info
Structure Description Crystal structure of human RAC3 grown in the presence of Gpp(NH)p. PDB:2IC5
Method X-ray diffraction Resolution 1.90 Å Mutation Yes [3]
PDB Sequence
SMQAIKCVVV
9
GDGAVGKTCL
19
LISYTTNAFP
29
GEYIPFDNYS
41
ANVMVDGKPV
51

NLGLWDTAGQ
61
EDYDRLRPLS
71
YPQTDVFLIC
81
FSLVSPASFE
91
NVRAKWYPEV
101

RHHCPHTPIL
111
LVGTKLDLRD
121
DKDTIERLRD
131
KKLAPITYPQ
141
GLAMAREIGS
151

VKYLECSALT
161
QRGLKTVFDE
171
AIRAVLG
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GNP or .GNP2 or .GNP3 or :3GNP;style chemicals stick;color identity;select .A:10 or .A:11 or .A:12 or .A:13 or .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:28 or .A:33 or .A:37 or .A:57 or .A:58 or .A:59 or .A:60 or .A:61 or .A:116 or .A:118 or .A:119 or .A:158 or .A:159 or .A:160; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLY10
4.852
ASP11
3.893
GLY12
3.515
ALA13
2.982
VAL14
3.410
GLY15
3.078
LYS16
2.859
THR17
2.973
CYS18
2.843
PHE28
3.480
ILE33
3.508
PHE37
4.054
Residue
Distance (Å)
ASP57
4.811
THR58
4.166
ALA59
4.135
GLY60
3.198
GLN61
2.951
LYS116
3.152
ASP118
2.741
LEU119
3.513
SER158
3.395
ALA159
2.981
LEU160
3.196
References  Top
REF 1 Crystal Structure of the Human Rac3 in Complex with Gdp
REF 2 The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 1 (PAK1).
REF 3 Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.

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