Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T06525 Target Info
Target Name Rac family small GTPase 3 (RAC3)
Synonyms p21-Rac3; Ras-related C3 botulinum toxin substrate 3
Target Type Literature-reported Target
Gene Name RAC3
UniProt ID
RAC3_HUMAN
Ligand General Information  Top
Ligand Name Guanosine-5'-Diphosphate Ligand Info
Canonical SMILES C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
InChI 1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKey QGWNDRXFNXRZMB-UUOKFMHZSA-N
PubChem Compound ID 135398619
Drug Binding Sites of Target  Top
PDB ID: 2C2H      CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP
Method X-ray diffraction Resolution 1.85 Å Mutation No [1]
PDB Sequence
AIKCVVVGDG
12
AVGKTCLLIS
22
YTTNAFPGDN
39
YSANVMVDGK
49
PVNLGLWDTA
59

GQEDYDRLRP
69
LSYPQTDVFL
79
ICFSLVSPAS
89
FENVRAKWYP
99
EVRHHCPHTP
109

ILLVGTKLDL
119
RDDKDTIERL
129
RDKKLAPITY
139
PQGLAMAREI
149
GSVKYLECSA
159

LTQRGLKTVF
169
DEAIRAVL
Residue
Distance (Å)
ASP11
3.860
GLY12
3.897
ALA13
2.811
VAL14
3.330
GLY15
3.021
LYS16
2.700
THR17
2.919
CYS18
2.768
LEU19
4.880
PHE28
3.427
ASP57
4.796
PRO99
3.039
GLU100
3.452
HIS103
2.948
HIS104
2.871
Residue
Distance (Å)
PRO106
3.449
HIS107
2.912
LYS116
3.134
LEU117
3.759
ASP118
2.717
LEU119
3.491
ARG120
3.263
TYR139
3.337
PRO140
4.307
GLU156
2.654
SER158
3.483
ALA159
2.935
LEU160
3.157
ARG163
3.122
PDB ID: 2G0N      The Crystal Structure of the Human RAC3 in complex with GDP and Chloride
Method X-ray diffraction Resolution 1.90 Å Mutation No [2]
PDB Sequence
SMQAIKCVVV
9
GDGAVGKTCL
19
LISYTTNAFP
29
GEYIPTVFDN
39
YSANVMVDGK
49

PVNLGLWDTA
59
GQEDYDRLRP
69
LSYPQTDVFL
79
ICFSLVSPAS
89
FENVRAKWYP
99

EVRHHCPHTP
109
ILLVGTKLDL
119
RDDKDTIERL
129
RDKKLAPITY
139
PQGLAMAREI
149

GSVKYLECSA
159
LTQRGLKTVF
169
DEAIRAVLG
Residue
Distance (Å)
ASP11
3.876
GLY12
3.904
ALA13
2.834
VAL14
3.372
GLY15
3.084
LYS16
2.848
THR17
3.110
CYS18
2.771
LEU19
4.942
Residue
Distance (Å)
PHE28
3.568
ILE33
3.474
ASP57
4.868
LYS116
3.037
ASP118
2.837
LEU119
3.516
SER158
3.445
ALA159
2.944
LEU160
3.175
References  Top
REF 1 Crystal Structure of the Human Rac3 in Complex with Gdp
REF 2 The Crystal Structure of the Human RAC3 in complex with GDP and Chloride

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