Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02587 | Target Info | |||
| Target Name | Pyridoxal phosphate phosphatase (PDXP) | ||||
| Synonyms | PLPP; PLP phosphatase; PDXP | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PDXP | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Pyridoxal phosphate | Ligand Info | |||||
| Structure Description | Crystal structure of human pyridoxal 5'-phosphate phosphatase with its substrate | PDB:2CFT | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [1] |
| PDB Sequence |
MARCERLRGA
10 ALRDVLGRAQ20 GVLFDCDGVL30 WNGERAVPGA40 PELLERLARA50 GKAALFVSNN 60 SRRARPELAL70 RFARLGFGGL80 RAEQLFSSAL90 CAARLLRQRL100 PGPPDGAVFV 112 LGGEGLRAEL122 RAAGLRLAGD132 PSAGDGAAPR142 VRAVLVGYDE152 HFSFAKLREA 162 CAHLRDPECL172 LVATDRDPWH182 PLSDGSRTPG192 TGSLAAAVET202 ASGRQALVVG 212 KPSPYMFECI222 TENFSIDPAR232 TLMVGDRLET242 DILFGHRCGM252 TTVLTLTGVS 262 RLEEAQAYLA272 AGQHDLVPHY282 YVESIADLTE292 GLE
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Selenomethionine | Ligand Info | |||||
| Structure Description | Crystal structure of human pyridoxal phosphate phosphatase | PDB:2OYC | ||||
| Method | X-ray diffraction | Resolution | 1.72 Å | Mutation | No | [2] |
| PDB Sequence |
SLARCERLRG
9 AALRDVLGRA19 QGVLFDCDGV29 LWNGERAVPG39 APELLERLAR49 AGKAALFVSN 59 NSRRARPELA69 LRFARLGFGG79 LRAEQLFSSA89 LCAARLLRQR99 LPGPPDAPGA 109 VFVLGGEGLR119 AELRAAGLRL129 AGDPSAGAPR142 VRAVLVGYDE152 HFSFAKLREA 162 CAHLRDPECL172 LVATDRDPWH182 PLSDGSRTPG192 TGSLAAAVET202 ASGRQALVVG 212 KPSPYFECIT223 ENFSIDPART233 LVGDRLETDI244 LFGHRCGTTV255 LTLTGVSRLE 265 EAQAYLAAGQ275 HDLVPHYYVE285 SIADLTEGL
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LEU23
3.610
PHE24
4.446
ASP25
3.989
VAL57
3.073
SER58
4.040
ASN59
3.584
SER87
4.151
SER88
4.038
CYS91
3.558
VAL211
3.877
GLY212
3.880
LYS213
2.853
SER215
4.224
PRO216
3.143
TYR217
1.335
PHE219
1.326
GLU220
3.282
CYS221
3.215
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Tungstate | Ligand Info | |||||
| Structure Description | Crystal structure of human pyridoxal phosphate phosphatase | PDB:2OYC | ||||
| Method | X-ray diffraction | Resolution | 1.72 Å | Mutation | No | [2] |
| PDB Sequence |
SLARCERLRG
9 AALRDVLGRA19 QGVLFDCDGV29 LWNGERAVPG39 APELLERLAR49 AGKAALFVSN 59 NSRRARPELA69 LRFARLGFGG79 LRAEQLFSSA89 LCAARLLRQR99 LPGPPDAPGA 109 VFVLGGEGLR119 AELRAAGLRL129 AGDPSAGAPR142 VRAVLVGYDE152 HFSFAKLREA 162 CAHLRDPECL172 LVATDRDPWH182 PLSDGSRTPG192 TGSLAAAVET202 ASGRQALVVG 212 KPSPYFECIT223 ENFSIDPART233 LVGDRLETDI244 LFGHRCGTTV255 LTLTGVSRLE 265 EAQAYLAAGQ275 HDLVPHYYVE285 SIADLTEGL
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal Structure of Human Pyridoxal 5-Phosphate Phosphatase | ||||
| REF 2 | Structural genomics of protein phosphatases. J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. | ||||
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