Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T02587 Target Info
Target Name Pyridoxal phosphate phosphatase (PDXP)
Synonyms PLPP; PLP phosphatase; PDXP
Target Type Literature-reported Target
Gene Name PDXP
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PLPP_HUMAN
Ligand General Information  Top
Ligand Name Selenomethionine Ligand Info
Canonical SMILES C[Se]CCC(C(=O)O)N
InChI 1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)
InChIKey RJFAYQIBOAGBLC-UHFFFAOYSA-N
PubChem Compound ID 15103
Drug Binding Sites of Target  Top
PDB ID: 2OYC      Crystal structure of human pyridoxal phosphate phosphatase
Method X-ray diffraction Resolution 1.72 Å Mutation No [1]
PDB Sequence
SLARCERLRG
9
AALRDVLGRA
19
QGVLFDCDGV
29
LWNGERAVPG
39
APELLERLAR
49

AGKAALFVSN
59
NSRRARPELA
69
LRFARLGFGG
79
LRAEQLFSSA
89
LCAARLLRQR
99

LPGPPDAPGA
109
VFVLGGEGLR
119
AELRAAGLRL
129
AGDPSAGAPR
142
VRAVLVGYDE
152

HFSFAKLREA
162
CAHLRDPECL
172
LVATDRDPWH
182
PLSDGSRTPG
192
TGSLAAAVET
202

ASGRQALVVG
212
KPSPYFECIT
223
ENFSIDPART
233
LVGDRLETDI
244
LFGHRCGTTV
255

LTLTGVSRLE
265
EAQAYLAAGQ
275
HDLVPHYYVE
285
SIADLTEGL
Residue
Distance (Å)
LEU23
3.610
PHE24
4.446
ASP25
3.989
VAL57
3.073
SER58
4.040
ASN59
3.584
SER87
4.151
SER88
4.038
CYS91
3.558
VAL211
3.877
GLY212
3.880
LYS213
2.853
SER215
4.224
PRO216
3.143
TYR217
1.335
PHE219
1.326
GLU220
3.282
CYS221
3.215
Residue
Distance (Å)
ILE222
2.957
PRO230
3.468
THR233
3.468
LEU234
1.333
VAL236
1.335
GLY237
4.142
ASP243
3.661
ILE244
4.892
PHE246
3.773
GLY247
2.909
HIS248
4.651
CYS250
3.422
GLY251
1.333
THR253
1.326
THR254
3.458
VAL255
2.781
HIS281
3.581
PDB ID: 2P69      Crystal Structure of Human Pyridoxal Phosphate Phosphatase with PLP
Method X-ray diffraction Resolution 2.25 Å Mutation No [1]
PDB Sequence
SLARCERLRG
9
AALRDVLGRA
19
QGVLFDCDGV
29
LWNGERAVPG
39
APELLERLAR
49

AGKAALFVSN
59
NSRRARPELA
69
LRFARLGFGG
79
LRAEQLFSSA
89
LCAARLLRQR
99

LPGPPAVFVL
113
GGEGLRAELR
123
AAGLRLAGDP
133
SAGAPRVRAV
146
LVGYDEHFSF
156

AKLREACAHL
166
RDPECLLVAT
176
DRDPWHPLSD
186
GSRTPGTGSL
196
AAAVETASGR
206

QALVVGKPSP
216
YFECITENFS
227
IDPARTLVGD
238
RLETDILFGH
248
RCGTTVLTLT
259

GVSRLEEAQA
269
YLAAGQHDLV
279
PHYYVESIAD
289
LTEGL
Residue
Distance (Å)
LEU23
3.660
PHE24
4.692
ASP25
3.815
VAL57
3.475
SER58
3.573
ASN59
3.004
PHE86
4.945
SER87
4.200
SER88
4.258
CYS91
3.754
VAL211
3.545
GLY212
3.577
LYS213
3.532
SER215
3.344
PRO216
2.998
TYR217
1.324
PHE219
1.328
GLU220
3.293
Residue
Distance (Å)
CYS221
3.172
ILE222
2.879
PRO230
3.453
THR233
3.444
LEU234
1.333
VAL236
1.326
GLY237
4.178
ASP243
3.637
PHE246
3.797
GLY247
2.855
HIS248
4.319
CYS250
3.289
GLY251
1.330
THR253
1.326
THR254
3.350
VAL255
2.797
HIS281
3.780
References  Top
REF 1 Structural genomics of protein phosphatases. J Struct Funct Genomics. 2007 Sep;8(2-3):121-40.

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