Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T01727 Target Info
Target Name HUMAN la-related protein 1 (LARP1)
Synonyms La ribonucleoprotein domain family member 1
Gene Name LARP1
Biochemical Class LARP family
UniProt ID
LARP1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 7N-Methyl-8-hydroguanosine-5'-triphosphate Ligand Info
Structure Description Crystal structure of LARP1-unique domain DM15 bound to m7GpppC PDB:5V87
Method X-ray diffraction Resolution 1.69 Å Mutation No [1]
PDB Sequence
HMQHPSHELL
803
KEGFTQHVYH
814
KYRRRCLNER
824
KRLGIGQSQE
834
MNTLFRFWSF
844

FLRDHFNKKM
854
YEEFKQLALE
864
DAKEGYRYGL
874
ECLFRYYSYG
884
LEKKFRLDIF
894

KDFQEETVKD
904
YEAGQLYGLE
914
KFWAFLKYSK
924
AKNLDIDPKL
934
QEYLGKF
Residue
Distance (Å)
SER882
2.109
TYR883
2.985
GLU886
1.639
GLU914
1.863
LYS915
2.876
Residue
Distance (Å)
TRP917
3.782
ALA918
2.811
PHE919
3.447
TYR922
2.645
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: 7-Methyl-guanosine-5'-triphosphate-5'-guanosine Ligand Info
Structure Description LARP1 DM15 FYRE (F844Y, R847E) mutant bound to m7GpppG dinucleotide (capG) PDB:6PW3
Method X-ray diffraction Resolution 2.34 Å Mutation Yes [2]
PDB Sequence
HPSHELLKEN
806
GFTQHVYHKY
816
RRRCLNERKR
826
LGIGQSQEMN
836
TLFRFWSYFL
846

EDHFNKKMYE
856
EFKQLALEDA
866
KEGYRYGLEC
876
LFRYYSYGLE
886
KKFRLDIFKD
896

FQEETVKDYE
906
AGQLYGLEKF
916
WAFLKYSKAK
926
NLDIDPKLQE
936
YLGKFRRLE
Residue
Distance (Å)
ARG840
4.942
SER843
2.372
TYR844
2.842
GLU847
1.688
CYS876
4.181
ARG879
2.337
TYR880
2.949
SER882
1.951
TYR883
2.614
GLU886
1.802
Residue
Distance (Å)
LYS887
4.458
TYR911
2.605
GLU914
2.061
LYS915
2.091
TRP917
3.873
ALA918
2.332
PHE919
2.794
LYS921
4.747
TYR922
2.869
References  Top
REF 1 La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs. Elife. 2017 Apr 7;6:e24146.
REF 2 Capturing the Mechanism Underlying TOP mRNA Binding to LARP1. Structure. 2019 Dec 3;27(12):1771-1781.e5.

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