Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T01727 Target Info
Target Name HUMAN la-related protein 1 (LARP1)
Synonyms La ribonucleoprotein domain family member 1
Gene Name LARP1
Biochemical Class LARP family
UniProt ID
LARP1_HUMAN
Ligand General Information  Top
Ligand Name 7N-Methyl-8-hydroguanosine-5'-triphosphate Ligand Info
Canonical SMILES CN1CN(C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
InChI 1S/C11H20N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h4,6-7,10,17-18H,2-3H2,1H3,(H,23,24)(H,25,26)(H2,20,21,22)(H3,12,13,14,19)/t4-,6-,7-,10-/m1/s1
InChIKey BUJQMJUTTBGELS-KQYNXXCUSA-N
PubChem Compound ID 135486126
Drug Binding Sites of Target  Top
PDB ID: 5V87      Crystal structure of LARP1-unique domain DM15 bound to m7GpppC
Method X-ray diffraction Resolution 1.69 Å Mutation No [1]
PDB Sequence
HMQHPSHELL
803
KEGFTQHVYH
814
KYRRRCLNER
824
KRLGIGQSQE
834
MNTLFRFWSF
844

FLRDHFNKKM
854
YEEFKQLALE
864
DAKEGYRYGL
874
ECLFRYYSYG
884
LEKKFRLDIF
894

KDFQEETVKD
904
YEAGQLYGLE
914
KFWAFLKYSK
924
AKNLDIDPKL
934
QEYLGKF
Residue
Distance (Å)
SER882
2.109
TYR883
2.985
GLU886
1.639
GLU914
1.863
LYS915
2.876
Residue
Distance (Å)
TRP917
3.782
ALA918
2.811
PHE919
3.447
TYR922
2.645
PDB ID: 5V4R      Crystal structure of LARP1-unique domain DM15 bound to m7GTP
Method X-ray diffraction Resolution 1.77 Å Mutation No [1]
PDB Sequence
HMQHPSHELL
803
KENGFTQHVY
813
HKYRRRCLNE
823
RKRLGIGQSQ
833
EMNTLFRFWS
843

FFLRDHFNKK
853
MYEEFKQLAL
863
EDAKEGYRYG
873
LECLFRYYSY
883
GLEKKFRLDI
893

FKDFQEETVK
903
DYEAGQLYGL
913
EKFWAFLKYS
923
KAKNLDIDPK
933
LQEYLGKFRR
943

LE
Residue
Distance (Å)
ARG879
2.920
TYR883
1.668
Residue
Distance (Å)
TYR911
2.112
LYS915
1.874
References  Top
REF 1 La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs. Elife. 2017 Apr 7;6:e24146.

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