Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00820 | Target Info | |||
| Target Name | Inward rectifier potassium channel Kir6.2 (KCNJ11) | ||||
| Synonyms | Potassium channel, inwardly rectifying, subfamily J, member 11; KCNJ11; KATP channel (Kir6.2/SUR2A); Inward rectifier K+ channel Kir6.2; IKATP | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | KCNJ11 | ||||
| Biochemical Class | Inward rectifier potassium channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Adenosine triphosphate | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form | PDB:6C3O | ||||
| Method | Electron microscopy | Resolution | 3.90 Å | Mutation | No | [1] |
| PDB Sequence |
RARFVSKKGN
41 CNVAHKNIRE51 QGRFLQDVFT61 TLVDLKWPHT71 LLIFTMSFLC81 SWLLFAMAWW 91 LIAFAHGDLA101 PSEGTAEPCV111 TSIHSFSSAF121 LFSIEVQVTI131 GFGGRMVTEE 141 CPLAILILIV151 QNIVGLMINA161 IMLGCIFMKT171 AQAHRRAETL181 IFSKHAVIAL 191 RHGRLCFMLR201 VGDLRKSMII211 SATIHMQVVR221 KTTSPEGEVV231 PLHQVDIPME 241 NGVGGNSIFL251 VAPLIIYHVI261 DANSPLYDLA271 PSDLHHHQDL281 EIIVILEGVV 291 ETTGITTQAR301 TSYLADEILW311 GQRFVPIVAE321 EDGRYSVDYS331 KFGNTIKVPT 341 PLCTARQLDE351 DHSLLEAL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular structure of human KATP in complex with ATP and ADP. Elife. 2017 Dec 29;6:e32481. | ||||
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